Dermatologic Treatments and Research

Cellular heterogeneity in hypertrophic burn scars in response to carbon dioxide laser therapy

This study uses single-cell RNA sequencing to analyze how hypertrophic burn scars respond to carbon dioxide laser therapy, identifying gene expression patterns and cell types associated with good or poor outcomes.

Single-cell RNA sequencing clarifies dermal fibroblast subset representation in vitro and reveals variable persistence of keloid disease-associated features

This study uses scRNA-seq to compare fibroblast subtypes in keloid and normal skin tissues with cultured fibroblasts, finding that some disease-associated features persist in vitro.

Natural killer cell dysfunction drives keloid pathogenesis

This study identifies NK cell dysfunction in keloids, showing IFN-γ suppresses fibroblast proliferation while AREG counteracts this, and systemic IFN-β drives NK cell exhaustion.

Non-invasive and painless mid-infrared modulation increases collagen in human and mouse skin

Mid-infrared modulation promotes collagen production in human and mouse skin without pain or trauma.

Multi-ancestry meta-analysis of keloids uncovers novel susceptibility loci in diverse populations

This study identifies 21 novel genetic loci associated with keloids through a multi-ancestry GWAS, highlighting integrin signaling and fibrosis pathways.

CD74+ fibroblasts proliferate upon mechanical stretching to promote angiogenesis in keloid

This study identifies CD74+ fibroblasts as key drivers of stretch-induced keloid progression through proliferation, angiogenesis, and migration.

Angiogenic Steroids Induce Pathologic Scarring in a Preclinical Swine Model Via Dysfunctional Extracellular Matrix Deposition.

This study shows testosterone increases fibrosis and scar strength in a swine model, suggesting androgenic steroids contribute to pathologic scarring through extracellular matrix changes.

Transcriptomic Analysis of Human Skin Wound Healing and Rejuvenation Following Ablative Fractional Laser Treatment

This study uses microarray profiling to analyze gene expression changes in human skin after ablative fractional laser treatment, showing gene expression reverses aging-related changes and requires multiple treatments for maximal rejuvenation.