Cerebrospinal fluid and hydrocephalus

The paper shows that an ASD-linked mutation in Katnal2 impairs ependymal ciliary motion, causing hydrocephalus and behavioral deficits in mice.

This study examines the relationship between perivascular spaces, cortisol, hypertension, and inflammation in cognitive impairment, finding significant associations and interactions.

The paper examines the ultrastructural pathways of brain waste clearance, highlighting the role of macrophages and arachnoid villi in transporting waste to the venous system.

This study uses MRI and fluorescence imaging to show impaired glymphatic function in a mouse model of Huntington disease, suggesting it as a potential biomarker and therapeutic target.

The paper assesses sex-specific age-related changes in glymphatic function using resting-state fMRI in healthy aging participants, finding a decline after age 55, especially in females.

The paper investigates the organization of the central canal region in Rhesus monkeys and identifies CSF-contacting neurons as the only neuronal elements present in this area.

This study shows PTEN mutations cause ventriculomegaly and cortical network dysfunction through neural precursor and interneuron dysregulation, with mTORC1 inhibition offering therapeutic potential.

The paper shows that intracranial pressure increases during the dark phase in humans and rats, linked to elevated cerebrospinal fluid secretion, partly due to increased choroid plexus transport activity.

The paper uses [64Cu]Cu-albumin PET to quantify age-related decline in CSF-lymphatic efflux in mice, showing slower clearance and reduced lymph node activity in aged mice.

This study shows that TNF-α inhibits multiciliated ependymal cell differentiation by upregulating Notch pathway effectors, and that Notch inhibition rescues this process, suggesting a potential therapeutic target for hydrocephalus.

This study examines the effects of focal brain injury on intracerebral circulation using a closed head injury model in mice, finding reduced circulation on both ipsilateral and contralateral sides one week post-injury.

This study shows that GIT 27 reduces astrocyte attachment and cytokine levels when used as a pre-treatment for shunt insertion.

This paper introduces a non-contrast spin-labeling MRI technique to quantify CSF outflow in humans and finds that CSF flow metrics decline with age.

The paper shows sleep cycle-dependent changes in perivascular spaces enhance cerebrospinal fluid flow and solute transport in sleeping mice.

This study characterizes non-human primate dura in health and neurodegeneration, revealing a complex lymphatic system and disease-specific biomarker associations.

This study identifies a mutation in Trim71 that causes congenital hydrocephalus by impairing stem cell differentiation through repression of Lsd1 mRNA translation.

This study shows altered brain fluid circulation dynamics in a mature-onset AD mouse model, linked to amyloid plaque burden and neuroinflammation.

This study uses dynamic MRI with contrast agent to assess CSF clearance pathways in humans, finding age-related decline and a link between peri-olfactory pathway function and sleep/cognitive health.

This study identifies lysophosphatidic acid (LPA) as a biomarker for posthemorrhagic hydrocephalus and shows it drives CSF accumulation through TRPV4-induced hyperactivation of NKCC1.

This study shows acetazolamide reduces intracranial pressure directly by acting on the choroid plexus in rats, without relying on systemic effects.

This study maps CSF pathways in the CNS using gold nanoparticle enhanced X-ray microtomography and identifies region-specific circulation patterns affecting stem cell and neuronal populations.

This study uses MRI to track CSF flow in juvenile mouse brains, finding increased permeability in specific regions until postnatal week 1.

This study shows that photostimulation of meningeal lymphatic vessels in mice with intraventricular hemorrhage reduces mortality and improves recovery by enhancing red blood cell clearance.

The paper reconciles fluid dynamics theory, simulation, and in vivo measurements of CSF flow in mouse brains by applying realistic boundary conditions.

The paper shows that coupling between global brain activity and CSF inflow correlates with Alzheimer's disease pathology using ADNI data.

This study shows that glutamate and GABA modulate glymphatic clearance of amyloid β through distinct mechanisms involving pulsation and AQP4, with potential therapeutic implications for Alzheimer's disease.

The paper identifies a specialized neuro-texture in the caudal thoracic spinal cord of monkeys, consisting of NADPH-d positive neurons and plexus structures that may function as CSF sensors.

This paper presents numerical simulations of cerebrospinal fluid dynamics models to confirm and extend theoretical results from a mathematical perspective.

This study examines the relationship between cerebral autoregulation, CSF outflow resistance, and surgical outcomes in normal pressure hydrocephalus patients.