Cerebrospinal fluid and hydrocephalus

How brain pulsations drive solute transport in thecranial subarachnoid space: insights from a toymodel

This study develops a toy model to investigate how brain pulsations drive solute transport in the cranial subarachnoid space, showing that steady flows significantly affect concentration profiles and clearance efficiency.

Patient-informed biomechanical modelling reveals mechanical mechanism of brain damage in idiopathic normal pressure hydrocephalus

This paper develops a biomechanical model of the brain to show that ventricular enlargement in iNPH causes mechanical strain in white matter, contributing to brain damage.

Oscillatory flow and steady streaming of cerebrospinal fluid in cranial subarachnoid space

This study models oscillatory and steady streaming flow of cerebrospinal fluid in the cranial subarachnoid space using a lubrication-based framework, showing that oscillatory forcing enhances solute transport.

Aging macaques bridge the translational gap in perivascular space biology

This study shows that aging rhesus macaques exhibit age-dependent perivascular space burden, mirroring human patterns, and validates MRI-detected structures as perivascular spaces.

Oscillating Hypercapnia Induces Neural Abundant Protein Efflux and Potential Depletion in Health and Chronic Traumatic Brain Injury

This study shows that hypercapnia temporarily increases brain-to-blood protein clearance in TBI and healthy individuals, with effects moderated by brain atrophy.

Gut-Brain Hydraulics: Brain motion and CSF circulation is driven by mechanical coupling with the abdomen

This study shows brain motion in mice is driven by abdominal muscle contractions and linked to hydraulic fluid flow, impacting brain health through mechanical coupling with the abdomen.

Distinct Effects of Aging and Klotho Deletion on the Choroid Plexus

This study examines how aging and Klotho deletion affect choroid plexus structure and function, finding that Klotho deficiency increases age-related calcification in specific regions.

Stretch and flow at the gliovascular interface: high-fidelity modelling of astrocyte endfeet

The paper develops a high-fidelity computational model of astrocyte endfeet and perivascular spaces to study fluid dynamics and mechanical interactions in response to vascular pulsations.

Integrative genomics elucidates the evolutionary, temporal, and developmental origins of a hydrocephalus risk gene

The paper characterizes the evolutionary origin and expression of MAEL in the developing human brain and finds reduced MAEL expression in hydrocephalus brain tissue.

Modulation of neurofluid fluctuation frequency by baseline carbon dioxide in awake humans: the role of the autonomic nervous system

This study investigates how baseline CO2 levels modulate neurofluid dynamics in awake humans, showing that autonomic nervous system regulation affects flow through frequency changes rather than amplitude.

The impact of human brain geometry on the transport of an intrathecal tracer

This study predicts tracer distribution in the brain using geometric MRI data, showing strong correlation with actual tracer enrichment in patients with similar diagnoses.

Impact of infusion conditions and anesthesia on CSF tracer dynamics in mouse brain

This study examines how infusion location, rate, and anesthesia affect CSF tracer dynamics in mice using Gd-DTPA and MRI.

In vitro design of intrathecal drug administration therapies

This paper develops an in vitro model of the human CNS to study intrathecal drug dispersion and pharmacokinetics, providing reliable data for therapy design.

Biological sex and BMI influence the longitudinal evolution of adolescent and young adult MRI-visible perivascular spaces

This study examines how biological sex and BMI affect the longitudinal changes in MRI-visible perivascular spaces (MV-PVS) in adolescents and young adults.

Genetically determined alterations in inflammation and infection-associated genes are associated with hydrocephalus in patients of African Ancestry

The paper identifies TMEM208 as a transcriptome-wide predictor of hydrocephalus in African ancestry patients, linking it to inflammation and infection pathways.

Evidence for reduced choroid plexus volume in the aged brain

This study finds a significant reduction in choroid plexus volume in aged mice using two MRI protocols, supporting previous histology findings of age-related structural changes.

Advection versus diffusion in brain ventricular transport

This study uses computational modeling and experiments to show that cilia drive advection of large particles while diffusion is key for small solute transport in brain ventricles.

Quantitative evaluation of normal cerebrospinal fluid flow in the Sylvian aqueduct and perivascular spaces of the middle cerebral artery and circle of Willis via 2D phase-contrast MR imaging

This study measures CSF flow in the circle of Willis and middle cerebral artery using phase-contrast MRI, establishing baseline parameters and showing differences compared to the Sylvian aqueduct.

Cholinergic basal forebrain neurons regulate vascular dynamics and cerebrospinal fluid flux

The paper shows that cholinergic basal forebrain neurons influence vascular-CSF coupling and glymphatic flux in mice, suggesting a neurovascular mechanism for waste clearance in the brain.

A Novel Microsurgical Rat Model of Cervical Lymph Node-to-Vein Anastomosis (LNVA) for Studying Brain Lymphatic Outflow

This paper establishes a rat model for cervical lymph node-to-venous anastomosis to study brain lymphatic clearance and its role in neurodegeneration.

Relationships between measures of neurovascular integrity and fluid transport in aging: a multi-modal neuroimaging study

This study examines relationships between MRI-based measures of neurovascular integrity and fluid transport in older adults, finding age-related changes and stable inter-relationships among these metrics.

CSF pressure in fetal mice in utero: External factors pressurize the intraventricular space

The paper measures intraventricular CSF pressure in fetal mice in utero and shows it is influenced by external factors.

Sequential emergence and contraction of epithelial subtypes in the prenatal human choroid plexus revealed by a stem cell model

Apolipoprotein-L1 G1 variant contributes to hydrocephalus but not to atherosclerosis in apolipoprotein-E knock-out mice

The paper investigates the role of APOL1 variants in cardiovascular and neurological diseases using mice, finding APOL1-G1 contributes to hydrocephalus but not atherosclerosis.

Total cerebral blood volume changes drive macroscopic cerebrospinal fluid flux in humans

Perivascular and parenchymal fluid characteristics are related to age and cognitive performance across the lifespan

This study examines age-related changes in perivascular and parenchymal fluid flow characteristics and their relationship with cognitive performance across development and aging.

The Spatial Patterns and Determinants of Cerebrospinal Fluid Circulation in the Human Brain

This study develops a framework to analyze CSF flow patterns using low-b dMRI and identifies factors influencing these patterns across different brain regions.

Lumped parameter simulations of cervical lymphatic vessels: dynamics of murine cerebrospinal fluid efflux from the skull

The paper models CSF drainage through cervical lymphatic vessels using a lumped parameter approach, revealing key physical characteristics and flow dynamics.

Dysregulated Neurofluid Coupling as a New Noninvasive Biomarker for Primary Progressive Aphasia

This study identifies reduced BOLD-CSF coupling as a biomarker for Primary Progressive Aphasia, linking glymphatic dysfunction to clinical and structural brain changes.

Enhancing glymphatic function with very low-intensity ultrasound via the transient receptor potential vanilloid-4-aquaporin-4 pathway

Very low-intensity ultrasound enhances glymphatic influx via the TRPV4-AQP4 pathway in astrocytes without causing brain damage.