Lymphatic System and Diseases

Cdc42 is required for lymphatic branching, maturation and valve formation during embryonic development

This study shows that Cdc42 is essential for lymphatic vessel branching, maturation, and valve formation during embryonic development.

RASA1-driven cellular export of collagen IV is required for the development of lymphovenous and venous valves in mice

This study shows that RASA1 is required for the development of lymphovenous and venous valves by regulating collagen IV export from endothelial cells in mice.

Organogenesis and Distribution of the Ocular Lymphatic Vessels in the Anterior Eye: Implication to Glaucoma Surgery Site Selection

This study characterizes the distribution and function of ocular lymphatics in mice and rats, showing nasal-side dominance and suggesting its clinical relevance for glaucoma surgery site selection.

S1P-S1PR1 activity controls VEGF-A signaling during lymphatic vessel development

This study shows that S1P-S1PR1 signaling promotes VEGF-A-dependent lymphatic endothelial cell proliferation and limits migratory responses during lymphatic vessel development.

MicroRNA-mediated control of developmental lymphangiogenesis

This study identifies miR-204 as a key regulator of lymphangiogenesis, showing its role in lymphatic vessel formation and its interaction with NFATC1.

Cerebrovascular Injuries Induce Lymphatic Invasion into Brain Parenchyma to Guide Vascular Regeneration in Zebrafish

This study shows that cerebrovascular injuries in zebrafish trigger lymphatic invasion into brain parenchyma, which helps resolve edema and guides vascular regeneration.

GATA2 controls lymphatic endothelial cell junctional integrity and lymphovenous valve morphogenesis through miR-126

This study identifies GATA2's role in maintaining lymphatic endothelial cell junctions and valve morphogenesis through regulation of miR-126.