Lymphatic System and Diseases

VEGF-C overexpression in kidney progenitor cells is a model of renal lymphangiectasia

This study creates a mouse model overexpressing VEGF-C in kidney progenitor cells, revealing increased lymphangiogenesis and a cystic kidney phenotype resembling human renal lymphangiectasia.

Endothelial Nitric Oxide Synthase Regulates Lymphatic Valve Specification By Controlling β-catenin Signaling During Embryogenesis

This study shows eNOS regulates lymphatic valve specification by controlling β-catenin signaling during embryogenesis, independent of nitric oxide production.

svep1 and tie1 genetically interact and affect aspects of facial lymphatic development in a Vegfc-independent manner

This study identifies a genetic interaction between svep1 and tie1 in zebrafish lymphatic development, independent of Vegfc, and links it to human glaucoma.

Single cell analysis of lymphatic endothelial cell fate specification and differentiation during zebrafish development

This study uses single-cell transcriptomics to investigate Prox1's role in lymphatic endothelial cell fate specification and differentiation in zebrafish, identifying new transcriptional targets and regulatory mechanisms.

Control of coronary lymphangiogenesis by epicardial VEGFC/D

This study identifies VEGFC and VEGFD as essential mediators of coronary lymphangiogenesis, with a sex-specific role for VEGFD in females.

The blood vasculature instructs lymphatics patterning in a SOX7-dependent manner

This study identifies SOX7 as a transcription factor in blood vascular endothelial cells that represses Vegfc expression, influencing lymphatic vessel patterning in mice.

The phosphodiesterase 2A regulates lymphatic endothelial development via cGMP-mediated control of Notch signaling

This study identifies PDE2A as a regulator of lymphatic endothelial development through cGMP-mediated control of Notch signaling, showing its role in junction maturation and cell cycle arrest.

Investigation of clinical characteristics and genome associations in the UK Lipoedema cohort

This study conducts a GWAS on a UK lipoedema cohort, identifying genetic loci associated with the disease, including those related to lipoma formation and hormone biosynthesis.

The cardiopharyngeal mesoderm contributes to lymphatic vessel development

This study identifies the cardiopharyngeal mesoderm as a non-venous source of lymphatic endothelial cells contributing to craniofacial and cardiac lymphatic networks.

Cdh5-lineage independent origin of dermal lymphatic vessels revealed by temporally restricted lineage tracing

The paper uses lineage tracing to show that dermal lymphatic vessels can originate from sources other than the Cdh5 lineage, highlighting the importance of temporal control in lineage tracing.

Direct specification of lymphatic endothelium from non-venous angioblasts

This study identifies a direct origin of lymphatic endothelial cells from non-venous angioblasts, challenging the prevailing view that they primarily derive from venous endothelium.

Proper migration of lymphatic endothelial cells requires survival and guidance cues from arterial mural cells

This study identifies that arterial mural cells provide survival and guidance cues via Cxcl12a/b and Vegfc to promote lymphatic endothelial cell migration in zebrafish.

The growth and expansion of meningeal lymphatic networks are affected in craniosynostosis

This study shows that meningeal lymphatic networks are impaired in craniosynostosis models, leading to reduced lymphatic drainage and potential waste clearance issues in the central nervous system.

The asymmetric Pitx2 regulates intestinal muscular-lacteal development and protects against fatty liver disease

The paper identifies the role of asymmetric Pitx2 in intestinal lacteal development and shows its protective effect against fatty liver disease through lymphatic-dependent lipid transport.

Unique functions for Notch4 in murine embryonic lymphangiogenesis

This study identifies distinct roles for Notch4 and canonical Notch signaling in embryonic dermal lymphangiogenesis using mouse models.

Urgent Brain Vascular Regeneration Occurs via Lymphatic Transdifferentiation

This study shows that urgent brain vascular regeneration after ischemic stroke occurs through lymphatic transdifferentiation, mediated by EphrinB2a/EphB4a/Notch signaling in zebrafish.

Pilot identification of the Live-1/Prox-1 expressing lymphatic vessels and lymphatic elements in the unaffected and affected human brain

The paper identifies Lyve-1/Prox-1-expressing lymphatic vessels and elements in both unaffected and affected human brains, suggesting their role in cerebral lymphatic function.

The olfactory organ is a unique site for resident neutrophils in the brain

This study identifies the olfactory organ as the only brain region containing resident neutrophils and reveals its unique lymphatic vasculature and immune response to damage.

Pkd1 and Wnt5a genetically interact to control lymphatic vascular morphogenesis in mice

This study identifies a genetic interaction between Pkd1 and Wnt5a in controlling lymphatic vascular morphogenesis in mice, showing mutual suppression of lymphatic defects.

Generation of specialized blood vessels through transdifferentiation of lymphatic endothelial cells

This study shows that lymphatic endothelial cells can transdifferentiate into blood vessel endothelial cells in zebrafish, linking cell origin to function in vascular development and regeneration.

Nasal BCG Exposure Accelerates Dural Lymphatics Development via Macrophages' Role in Newborn Mice

This study shows that repeated nasal BCG exposure accelerates dural lymphatics development in neonatal mice, especially when combined with intracutaneous BCG injection.

Vasohibin-1 mediated tubulin detyrosination selectively regulates secondary sprouting and lymphangiogenesis in the zebrafish trunk

This study shows that Vasohibin-1 mediates tubulin detyrosination in zebrafish endothelial cells, selectively regulating secondary sprouting and lymphangiogenesis in the trunk.

Tissue-resident macrophages regulate lymphatic vessel growth and patterning in the developing heart

This study shows that tissue-resident macrophages are essential for lymphatic vessel growth and patterning during heart development by remodeling the vascular plexus.

Live Imaging of Intracranial Lymphatics in the Zebrafish

The paper identifies a meningeal lymphatic network in zebrafish, comparable to mammals, and demonstrates its function in draining brain interstitial fluid and immune cell trafficking.

AIBP-CAV1-VEGFR3 axis dictates lymphatic cell fateand controls lymphangiogenesis

This study identifies the AIBP-CAV1-VEGFR3 axis as a regulator of lymphangiogenesis, showing that AIBP-mediated cholesterol efflux enhances VEGFC-driven lymphatic vessel formation.

Tbx1 interacts genetically with Vegfr3 to regulate cardiac lymphangiogenesis in mice

This study shows that Tbx1 and Vegfr3 interact genetically to regulate cardiac lymphangiogenesis, with dosage balance required for proper vessel development.

S1PR1 regulates the quiescence of lymphatic vessels by inhibiting laminar shear stress-dependent VEGF-C signaling

This study identifies S1PR1 as a regulator of lymphatic vessel quiescence by inhibiting LSS-dependent VEGF-C signaling in lymphatic endothelial cells.

A single-cell transcriptional roadmap of the mouse and human lymph node lymphatic vasculature

This paper uses single-cell transcriptomics to map the transcriptional organization of lymphatic endothelial cells in mouse and human lymph nodes, identifying distinct subsets and their functional roles.

The p53-p21 axis plays a central role in lymphatic homeostasis and disease

This study shows that overactive p53 in lymphatic endothelial cells causes lymphatic defects in mice and human tissues, and normalizing p53 restores lymphatic function.

BACH family members regulate angiogenesis and lymphangiogenesis by modulating VEGFC expression

This study identifies BACH family members as regulators of VEGFC expression, impacting angiogenesis and lymphangiogenesis in zebrafish and mouse models.