Lymphatic System and Diseases

Lymphangiogenesis is Critical for Healing and Survival in a Murine Model of Laryngotracheal Injury

This study shows that lymphangiogenesis is essential for healing and survival after laryngotracheal injury in mice, as blocking it leads to worse outcomes.

Autophagy in lymphatic endothelial cells promotes lung metastasis

This study shows that autophagy in lymphatic endothelial cells promotes lung metastasis by altering lymphatic pathways and immune niches.

SVEP1 enables efficient binding of Angiopoietin-2 to the TIE1 receptor, allowing receptor phosphorylation and downstream signaling

This study identifies SVEP1 as a mediator of ANG2-TIE1 binding, leading to TIE1 phosphorylation and downstream signaling in lymphatic endothelial cells.

A new Mmrn1-CreERT2 Mouse Model for High-Fidelity Labeling of Adult Lymphatic Endothelium

The paper introduces an Mmrn1-CreERT2 mouse model that enables high-fidelity labeling of adult lymphatic endothelium without recombination in non-lymphatic CNS populations.

Computational modeling of VEGF-A signaling predicts lymphatic junction state

The paper develops a computational model of VEGF-A signaling in lymphatic endothelial cells to predict junction state transitions and shows how obesity affects these dynamics in different LEC populations.

The lymphangiogenic Ccbe1-Adamts-Vegfc axis shapes cerebrovascular regionalization via selective patterning of fenestrated vascular beds

The paper identifies the Ccbe1-Adamts-Vegfc axis as critical for cerebrovascular regionalization in zebrafish by regulating fenestrated vascular patterning.

Using a 3-step semi-automated image analysis pipeline to quantify differences in VE-cadherin junction morphology in lymphatic endothelial cells in vitro

This paper develops a 3-step image analysis pipeline to quantify VE-cadherin junction morphology in lymphatic endothelial cells, identifying new metrics that distinguish button-like and zipper-like junctions.

Lymphatic constraint of germinal centers optimizes protective antibody responses

This study shows that lymphatic remodeling in skin and lymph nodes constrains germinal center size and function to optimize protective antibody responses during viral infection.

Fluid-Structure Interaction Dynamics of Cervical Lymphatic Vessel Pumping and Valvular Function

This study develops a computational model of cervical lymphatic vessels to simulate CSF drainage and valve function, revealing dynamics of pumping and transport under different pressure conditions.

Physiological Aging and Cardiovascular Disease Distinctly Remodel the Human Cardiac Lymphatic Endothelium

This study identifies age- and disease-specific remodeling of cardiac lymphatic endothelial cells through single-nucleus transcriptomics and spatial analysis.

Lymphatic ERG Governs Junctional Plasticity and Fluid Clearance via an EDNRB Signaling Axis in Pulmonary Fibrosis

This study identifies ERG-EDNRB signaling in lymphatic endothelial cells as critical for junctional plasticity and fluid clearance in pulmonary fibrosis, showing that its disruption protects against fibrosis.

Cholesterol-Mediated Modulation of Collecting Lymphatic Vessel Contractility: Exploring Cholesterol Depletion as a Therapeutic Alternative to Improve Lymphatic Function in Hypercholesterolemia

This study shows that cholesterol depletion with cyclodextrins improves lymphatic vessel contractility in mice, suggesting a potential therapeutic strategy for lymphedema.

Pan-Peroxisome Proliferator-Activated Receptor Agonist IVA337 Alleviates Secondary Lymphedema via Inhibiting TGFβ/SMAD2/3 Signaling Pathway

This study shows that IVA337 reduces secondary lymphedema in mice by inhibiting the TGFβ/SMAD2/3 pathway, improving lymphatic function and preventing fibrosis.

A NON-CANONICAL ROLE FOR NOTCH3 IN BUILDING THE INTESTINAL LYMPHATIC NICHE

This study identifies Notch3 as a non-canonical organizer of intestinal lymphatic niche development through PDGFR{beta} cell signaling.

Bone Lymphatic Endothelial Cells Form a Distinct Skeletal Population and Drive Skeletal Repair

The paper identifies bone lymphatic endothelial cells as a distinct population that drives skeletal repair and shows that their dysfunction contributes to mandibular diseases.

Lymphatic endothelial cells regulate neutrophil phenotypes and function in a microphysiological model of infection

This study shows lymphatic endothelial cells influence neutrophil migration, phagocytosis, and NETosis in a 3D infection model, with differential effects based on bacterial type.

Lymphatics unload VEGFR3 in response to the alteration of VEGFR2-mediated transcriptional programs

This study shows that VEGFR2 is essential for maintaining lymphatic endothelial identity and its loss alters transcriptional programs, reducing VEGFR3-mediated lymphangiogenesis.

CXCL12/CXCR4 Governs Lymphatic Valve Formation Through Flow Dependent AKT/FOXO1/FOXC2 Activation

This study identifies CXCL12/CXCR4 signaling as critical for lymphatic valve formation through flow-dependent AKT/FOXO1/FOXC2 activation, offering potential therapeutic strategies for lymphedema.

Jagged-1+ Tregs Mediate Lymphatic Remodeling in Tumour-Draining Lymph Nodes

This study shows that Jag1-expressing regulatory T cells (Tregs) in tumor-draining lymph nodes (tdLNs) are essential for lymphatic remodeling and niche formation during melanoma progression.

Intravital imaging of age-related conjunctival lymphatic changes on the ocular surface

This study uses intravital imaging to examine age-related changes in conjunctival lymphatics, finding reduced vascular branching and functional impairments in aged mice.

Vegfc-Vegfr3-Dependent Lymphatic Sprouting Requires Apelin Signaling

This study shows Apelin signaling is essential for Vegfc-Vegfr3-dependent lymphatic sprouting and promotes LEC migration.

Langerhans cells regulate immunity in adulthood by regulating postnatal dermal lymphatic development

This study shows that Langerhans cells regulate postnatal dermal lymphatic development, which in turn controls adult immune responses.

A GATA2-PROX1-FOXC2 regulatory axis integrates shear stress signaling with lymphatic vascular development

The paper identifies a GATA2-PROX1-FOXC2 regulatory axis that integrates shear stress signaling with lymphatic vascular development, showing dosage-dependent cooperation between GATA2 and FOXC2.

Blocking glutamine transport normalizes lymphatic vessels in hypoxic environments by attenuating glycolysis

This study shows that blocking glutamine transport reduces glycolysis and improves lymphatic vessel formation in hypoxic conditions by affecting LEC proliferation and migration.

GLP-1R Agonism Directly Improves the Pumping Capacity of Murine Collecting Lymphatic Vessels

This study shows GLP-1R agonism directly improves lymphatic pumping capacity in mice through vasodilation and enhanced contractile function, independent of systemic weight loss effects.

Development and Function of Ovarian Lymphatic Vasculature

This study investigates the development and function of the ovarian lymphatic vasculature in mice, revealing its origin and the role of VEGF-C/VEGFR-3 signaling in preventing fibrosis and ovarian aging.

Periosteal and periarticular compartments house lymphatic vessels in bone

This study identifies that lymphatic vessels in bone are confined to periosteal and periarticular compartments and absent from bone marrow.

Signaling scaffold Shoc2 regulates lymphangiogenesis by suppressing mTORC1-mediated IFN responses.

This study identifies Shoc2 as a critical regulator of lymphangiogenesis by suppressing mTORC1-mediated IFN responses, leading to lymphatic vasculature loss and cellular senescence.

Fluid forces control structural remodeling of blind-ended lymphatic microvessels

This study shows how fluid forces and VEGF-C drive lymphangiogenesis and structural remodeling of blind-ended lymphatic vessels using a microphysiological system.

Untargeted metabolomic profiling reveals mTORC1-dependent regulation of amino acid utilization in lymphatic endothelial cells

The paper uses untargeted metabolomic profiling to show that mTORC1 regulates amino acid utilization in lymphatic endothelial cells, affecting glutaminolysis and branched-chain amino acid metabolism.