Lymphatic System and Diseases

Autophagy in lymphatic endothelial cells promotes lung metastasis

This study shows that autophagy in lymphatic endothelial cells promotes lung metastasis by altering lymphatic pathways and immune niches.

SVEP1 enables efficient binding of Angiopoietin-2 to the TIE1 receptor, allowing receptor phosphorylation and downstream signaling

This study identifies SVEP1 as a mediator of ANG2-TIE1 binding, leading to TIE1 phosphorylation and downstream signaling in lymphatic endothelial cells.

Lymphatic constraint of germinal centers optimizes protective antibody responses

This study shows that lymphatic remodeling in skin and lymph nodes constrains germinal center size and function to optimize protective antibody responses during viral infection.

Fluid-Structure Interaction Dynamics of Cervical Lymphatic Vessel Pumping and Valvular Function

This study develops a computational model of cervical lymphatic vessels to simulate CSF drainage and valve function, revealing dynamics of pumping and transport under different pressure conditions.

Pan-Peroxisome Proliferator-Activated Receptor Agonist IVA337 Alleviates Secondary Lymphedema via Inhibiting TGFβ/SMAD2/3 Signaling Pathway

This study shows that IVA337 reduces secondary lymphedema in mice by inhibiting the TGFβ/SMAD2/3 pathway, improving lymphatic function and preventing fibrosis.

Lymphatic endothelial cells regulate neutrophil phenotypes and function in a microphysiological model of infection

This study shows lymphatic endothelial cells influence neutrophil migration, phagocytosis, and NETosis in a 3D infection model, with differential effects based on bacterial type.

Lymphatics unload VEGFR3 in response to the alteration of VEGFR2-mediated transcriptional programs

This study shows that VEGFR2 is essential for maintaining lymphatic endothelial identity and its loss alters transcriptional programs, reducing VEGFR3-mediated lymphangiogenesis.

Jagged-1+ Tregs Mediate Lymphatic Remodeling in Tumour-Draining Lymph Nodes

This study shows that Jag1-expressing regulatory T cells (Tregs) in tumor-draining lymph nodes (tdLNs) are essential for lymphatic remodeling and niche formation during melanoma progression.

Langerhans cells regulate immunity in adulthood by regulating postnatal dermal lymphatic development

This study shows that Langerhans cells regulate postnatal dermal lymphatic development, which in turn controls adult immune responses.

GLP-1R Agonism Directly Improves the Pumping Capacity of Murine Collecting Lymphatic Vessels

This study shows GLP-1R agonism directly improves lymphatic pumping capacity in mice through vasodilation and enhanced contractile function, independent of systemic weight loss effects.

Signaling scaffold Shoc2 regulates lymphangiogenesis by suppressing mTORC1-mediated IFN responses.

This study identifies Shoc2 as a critical regulator of lymphangiogenesis by suppressing mTORC1-mediated IFN responses, leading to lymphatic vasculature loss and cellular senescence.

Fluid forces control structural remodeling of blind-ended lymphatic microvessels

This study shows how fluid forces and VEGF-C drive lymphangiogenesis and structural remodeling of blind-ended lymphatic vessels using a microphysiological system.

Untargeted metabolomic profiling reveals mTORC1-dependent regulation of amino acid utilization in lymphatic endothelial cells

The paper uses untargeted metabolomic profiling to show that mTORC1 regulates amino acid utilization in lymphatic endothelial cells, affecting glutaminolysis and branched-chain amino acid metabolism.

Lymphatic Malformations with Activating KRAS Mutations Impair Lymphatic Valve Development Through Matrix Metalloproteinases

This study shows that KRAS mutations impair lymphatic valve development by upregulating MMPs, which degrade the valve ECM core.

VEGF-C-mediated Cardiac Lymphangiogenesis Promotes Inflammation Resolution in Autoimmune Acute Myocarditis in Mice

This study shows that VEGF-C treatment promotes cardiac lymphangiogenesis, reduces inflammation, and preserves heart function in autoimmune myocarditis in mice.

IFNγ-dependent metabolic reprogramming restrains an immature, pro-metastatic lymphatic state in melanoma

This study shows that IFNγ suppresses lymphatic vessel growth and metastasis by altering metabolism and immune function in melanoma.

Engineered lymphatic stroma model applications in central nervous system leukemia

This study uses engineered lymphatic models to investigate how leukemia cells interact with meningeal lymphatics and lymph nodes, showing their role in growth and migration.

Molecular determinants of cardiac lymphatic dysfunction in a chronic pressure-overload model

This study identifies molecular and cellular changes in cardiac lymphatics during pressure-overload, showing valve loss and barrier dysfunction in BALB/c mice but not C57BL/6J.

Breast Cancer Remodels Lymphatics in Sentinel Lymph Nodes

This study identifies changes in lymphatic endothelial cell subsets and increased MGP expression in metastatic sentinel lymph nodes from breast cancer patients.

Nanobody immunolabelling and three-dimensional imaging reveals spatially restricted LYVE1 expression by kidney lymphatic vessels in mice

The paper develops a nanobody-based method to label kidney lymphatic vessels in mice, revealing spatially restricted LYVE1 expression unique to the kidney.

Single-Cell and Spatial Transcriptomic Analyses Reveals the Dynamic Transcript Profiles of Myocardial Lymphangiogenesis post Myocardial Infarction

This study integrates single-cell and spatial transcriptomic data from mouse hearts post-myocardial infarction to identify functionally distinct lymphatic endothelial cell subtypes and their roles in tissue repair and inflammation.

TRPV4-Expressing Tissue-Resident Macrophages Regulate the Function of Collecting Lymphatic Vessels via Thromboxane A2 Receptors in Lymphatic Muscle Cells

This study identifies TRPV4-expressing macrophages as regulators of lymphatic vessel function through TXA2 receptors, suggesting therapeutic targets for lymphedema.

Engineered human lymph node stroma model for examining interstitial fluid flow and T cell egress

This study develops an engineered human lymph node stroma model to examine how interstitial fluid flow affects T cell egress and stromal cell behavior.

Lymphatic activation of ACKR3 signaling regulates lymphatic response after ischemic heart injury.

This study identifies ACKR3 signaling in cardiac lymphatics as critical for lymphangiogenesis, edema protection, and survival after ischemic heart injury.

Insulin regulates lymphatic endothelial function via palmitoylation

This study investigates how insulin regulates lymphatic endothelial function through palmitoylation, identifying CD36 as a mediator of this process.

Intravital imaging of pulmonary lymphatics in inflammation and metastatic cancer

This paper develops a technique for intravital imaging of pulmonary lymphatics in mice, revealing ventilation-dependent and -independent lymph flow and leukocyte migration during inflammation and cancer metastasis.

A Multiresolution Approach with Method-Informed Statistical Analysis for Quantifying Lymphatic Pumping Dynamics

This paper develops a multiresolution imaging and analysis approach to quantify lymphatic pumping dynamics, improving measurement reliability across species and conditions.

Mesenchymal Osr1+ cells regulate embryonic lymphatic vessel formation

This study identifies mesenchymal Osr1+ cells as regulators of embryonic lymphatic vessel formation by controlling LEC proliferation and migration.

Calcitonin gene-related peptide and intermedin induce phosphorylation of p44/42 MAPK in primary human lymphatic endothelial cells in vitro

This study shows CGRP and AM2/IMD induce p44/42 MAPK phosphorylation in primary human dermal lymphatic endothelial cells, with CGRP having a sustained effect.

Angpt1 binding to Tie1 regulates the signaling required for lymphatic vessel development in zebrafish

The paper identifies Angpt1/Tie1 signaling as essential for trunk lymphatic vessel development in zebrafish, showing Tie1 regulates Foxo1 localization and modulates Vegfc/Vegfr3 signaling.