Neuroscience and Neural Engineering

Revealing Spatiotemporal Circuit Information of Olfactory Bulb in Large-scale Neural Recordings

This paper introduces a biohybrid OB-CMOS platform to study spatiotemporal dynamics in olfactory bulb circuits using high-density electrode recordings.

Ultrastructural analysis of neuroimplant-parenchyma interfaces uncover remarkable neuroregeneration along-with barriers that limit the implant electrophysiological functions

The paper examines ultrastructural interfaces between neuroimplants and brain parenchyma, revealing regenerative processes and microglia-mediated barriers affecting electrophysiological function.

Neural population dynamics reveals disruption of spinal sensorimotor computations during electrical stimulation of sensory afferents

The paper examines how electrical stimulation of cutaneous afferents disrupts spinal processing of proprioceptive inputs and affects neural activity propagation to the somatosensory cortex.

Evaluation and resolution of many challenges of neural spike-sorting: a new sorter

This paper evaluates existing spike sorters and introduces a new method called full binary pursuit (FBP) that addresses multiple sorting challenges in neural recordings.

Intracortical probe arrays with silicon backbone and microelectrodes on thin polyimide wings enable long-term stable recordings in vivo

This paper develops a new neural probe with a silicon backbone and thin polyimide wings for long-term stable in vivo recordings in mice.

Three-dimensional spike localization and improved motion correction for Neuropixels recordings

This paper introduces methods for 3D spike localization and motion correction in Neuropixels recordings, improving spike sorting and neural activity tracking.

Transcriptional characterization of the glial response due to chronic neural implantation of flexible microprobes

This study characterizes the transcriptional response of glial cells to chronic implantation of flexible microprobes over 18 weeks, showing initial activation and eventual partial normalization.

Decoding of cortex-wide brain activity from local recordings of neural potentials

This study decodes large-scale cortical activity from local surface potentials using a recurrent neural network, showing that surface potentials contain rich information about neural activity across multiple regions.

Accurate localization of linear probe electrodes across multiple brains

The paper develops a workflow to accurately localize electrodes in Neuropixels probes across multiple brains using imaging and electrophysiological data.

Multifunctional optrode for opsin delivery, optical stimulation, and electrophysiological recordings in freely moving rats

This paper introduces a multifunctional optrode for optogenetics, enabling simultaneous drug delivery, optical stimulation, and electrophysiological recording in freely moving rats.

Light-weight Electrophysiology Hardware and Software Platform for Cloud-Based Neural Recording Experiments

The paper introduces Piphys, an open-source platform for neural recording that enables remote control and scalability through cloud-based software and low-cost hardware.

Pulsatile electrical stimulation creates predictable, correctable disruptions in neural firing

This study uses computational modeling to explain how pulsatile electrical stimulation affects neural firing rates and shows that these effects can be predicted and corrected.

Customizing Multifunctional Neural Interfaces through Thermal Drawing Process

This paper develops new fabrication methods for multifunctional neural interfaces that integrate electrical, optical, and microfluidic functions, demonstrating their long-term viability in mice.

A multimodal neuroprosthetic interface to record, modulate and classify electrophysiological correlates of cognitive function

This paper develops a multimodal neuroprosthetic interface to record, modulate, and classify electrophysiological correlates of cognitive function in rats, showing its potential for personalized therapy.

Human neuronal networks on micro-electrode arrays are a highly robust tool to study disease-specific genotype-phenotype correlations in vitro

The paper benchmarks MEA recordings from healthy hiPSC-derived neuronal networks to establish standards for experimental design and analysis, showing MEAs are robust for disease-phenotyping and drug discovery.

Perceptual responses to microstimulation frequency are spatially organized in human somatosensory cortex

This study investigates how microstimulation frequency affects perceptual responses in human somatosensory cortex, finding spatially organized effects on perceptual intensity and quality.

Rate-Based Decoding of Images from Multi-Region, High Resolution, Electrode Recordings In the Mouse Visual System

The paper compares deep networks and linear decoders for recovering visual stimuli from neural activity in mice, finding deep networks perform better.

An Adaptive Detection for Automatic Spike Sorting Based on Mixture of Skew-t distributions

This paper introduces an adaptive spike sorting algorithm that improves detection, alignment, and clustering of spikes by using a mixture of skew-t distributions, showing better precision and recall across datasets.

Chronic wireless neural population recordings with common marmosets

This paper develops a method for chronic wireless neural recordings in marmosets across multiple behaviors and brain states, validated through sensorimotor cortex activity tracking.

Small size of recorded neuronal structures confines the accuracy in direct axonal voltage measurements

The paper models the effects of recording instruments on axonal voltage measurements and shows how instrumentation distorts signals, offering a method to predict native waveforms from distorted recordings.

Dendritic calcium signals in rhesus macaque motor cortex drive an optical brain-computer interface

This paper demonstrates an optical brain-computer interface (oBCI) using dendritic calcium signals from rhesus macaques during motor tasks, achieving stable decoding of movement direction.

In vivo contactless brain stimulation via non-invasive and targeted delivery of magnetoelectric nanoparticles

This study demonstrates the use of magnetoelectric nanoparticles for non-invasive, targeted brain stimulation in mice, showing reliable neuronal activation and minimal immune response.

Monkey V1 epidural field potentials provide significant information about stimulus location, size, shape, and color.

Ion mechanism and parameter analysis of anodal-first waveforms for selective stimulation of C-fiber nerves

This study analyzes anodal-first waveforms to improve selective stimulation of C-fiber nerves over Aδ fibers using ion dynamics models.

Laser Ablation of the Pia Mater for Insertion of High-Density Microelectrode Arrays in a Translational Sheep Model

This paper describes a surgical technique using laser ablation to thin the pia mater in sheep, enabling safer insertion of high-density microelectrode arrays for neural recordings.

Transparent and flexible ECoG electrode arrays based on silver nanowire networks for neural recordings

This paper develops transparent and flexible ECoG electrodes using silver nanowire and IZO hybrid films, demonstrating improved electrical properties and compatibility with fluorescence microscopy.

Metal microdrive and head cap system for silicon probe recovery in freely moving rodent

The paper introduces a recoverable and reusable microdrive and head cap system for silicon probe recovery in freely moving rodents, reducing cost and experimental complexity.

Electrode pooling: How to boost the yield of switchable silicon probes for neuronal recordings

This paper introduces electrode pooling to increase the number of recording sites on silicon probes by using a single wire for multiple sites, demonstrating its feasibility on Neuropixels 1.0 and simulating its effectiveness.

What we can and what we cannot see with extracellular multielectrodes

The paper analyzes what information about brain current sources can be recovered or remains unobservable using extracellular multielectrode recordings, across different experimental setups.

Tracking long-term functional connectivity maps in human stem-cell-derived neuronal networks by holographic-optogenetic stimulation

The paper develops a holographic optogenetic platform to study long-term functional connectivity in human stem-cell-derived neuronal networks.