Neuroscience and Neural Engineering

Development of an objective index, neural activity score (NAS), reveals neural network ontogeny and treatment effects on microelectrode arrays

The paper develops a neural activity score (NAS) using PCA to quantify neural network development and treatment effects on MEAs, showing it accurately reflects expected results.

TetrODrive: An open-source microdrive for combined electrophysiology and optophysiology

TetrODrive is a low-cost, 3D-printable microdrive for electrophysiology and optophysiology in mice, enabling stable recordings and optotagging with high signal-to-noise ratio.

Neuropixels 2.0: A miniaturized high-density probe for stable, long-term brain recordings

The paper introduces Neuropixels 2.0, a high-density probe for long-term brain recordings, and demonstrates its stability across months in multiple labs and species.

Multi-modal artificial dura for simultaneous large-scale optical access and large-scaleelectrophysiology in non-human primate cortex

This paper introduces a multi-modal artificial dura for large-scale neural recording, imaging, and stimulation in non-human primates, showing reduced photo-induced artifacts and transparency.

Neurite growth kinetics regulation through hydrostatic pressure in a novel triangle-shaped neurofluidic system

This paper introduces a triangle-shaped neurofluidic system to study neurite growth kinetics in primary rat hippocampal neurons by applying hydrostatic pressure.

Diversify your workflow! - An inconvenient suggestion to analyze spike data from intracranial recordings

The paper evaluates spike detection methods in intracranial recordings, showing inconsistencies due to varying pipelines and suggesting consensus-based event acceptance to improve reliability.

A psychometric platform to collect somatosensory sensations for neuroprosthetic use

The paper introduces a psychometric platform to standardize the assessment of somatosensory sensations in neuroprosthetics, validated with amputees using implanted nerve interfaces.

Microchannel patterning strategies for in vitro structural connectivity modulation of neural networks

This study investigates how microchannel patterning strategies affect neuronal connectivity in microfluidic devices, showing they can modulate the direction and number of neurites between neuronal populations.

What do blind people "see" with retinal prostheses? Observations and qualitative reports of epiretinal implant users

This study qualitatively examines the perceptual experiences of individuals with retinal implants, finding that artificial vision is a learned skill involving distinct perceptual vocabulary and cognitive effort.

Multimodal in vivo recording using transparent graphene microelectrodes illuminates spatiotemporal seizure dynamics at the microscale

This paper introduces transparent graphene microelectrodes to simultaneously record microelectrocorticography and calcium fluorescence in vivo, revealing spatiotemporal seizure dynamics through non-negative matrix factorization.

Sea of Electrodes Array (SEA): Extremely Dense and High-Count Silicon-Based Electrode Array Technology for High-Resolution High-Bandwidth Interfacing with 3D Neural Structures

The paper introduces a new silicon-based micro-fabrication technology for creating high-density neural micro-probe arrays with thousands of electrodes, achieving a record density of 400 electrodes/mm2 in rat brain recordings.

Recording site placement on planar silicon-based probes affects neural signal quality: edge sites enhance acute recording performance

The paper investigates how the placement of recording sites on silicon probes affects neural signal quality, finding edge sites provide better signal quality than center sites in acute recordings.

A head-mounted multi-camera system for electrophysiology and behavior in freely-moving mice

This paper describes a head-mounted multi-camera system for monitoring behavior and electrophysiology in freely-moving mice, enabling comprehensive measurement of natural behaviors and eye movements.

Electrophysiological Phenotype Characterization of Human iPSC-Derived Neuronal Cell Lines by Means of High-Density Microelectrode Arrays

This study uses HD-MEAs to characterize electrophysiological phenotypes of iPSC-derived neurons and assess drug effects in Parkinson's and ALS models.

Compensation of physiological motion enables high-yield whole-cell recording in vivo

This paper develops a motion compensation method for whole-cell patch-clamp recordings in vivo, significantly improving gigaseal and recording yields in the mouse thalamus.

ION-Decoding: A Single-channel Interactive Offline Neural Decoding Algorithm for a large number of neurons

ION-Decoding is a single-channel, interactive, offline spike sorting algorithm that outperforms Wave_Clus in hit count but has higher false-positive errors.

Bayesian inference for biophysical neuron models enables stimulus optimization for retinal neuroprosthetics

This paper uses Bayesian inference to estimate parameters of retinal neuron models from imaging data and optimizes stimulus waveforms for retinal neuroprosthetics.

Decoding network-mediated retinal response to electrical stimulation: implications for fidelity of prosthetic vision

The paper compares retinal response fidelity to visual and electrical stimulation using single-cell modeling and decoding, finding that electrical stimulation activates fewer cells, requiring more stimulus presentations for equivalent decoding.

An approach for long-term, multi-probe Neuropixels recordings in unrestrained rats

This paper demonstrates a method for long-term, multi-probe Neuropixels recordings in freely moving rats over multiple months, showing high yield and probe reusability.

Through-scalp deep-brain stimulation in tether-free, naturally-behaving mice with widefield NIR-II illumination

This paper introduces an implant-free, tether-free optical neuromodulation technique using NIR-II light to stimulate deep brain regions in mice through the scalp.

Long-Term Performance of Utah Slanted Electrode Arrays and Intramuscular Electromyographic Leads Implanted Chronically in Human Arm Nerves and Muscles

This study evaluates the long-term performance of Utah Slanted Electrode Arrays and intramuscular leads in human amputees, showing initial decline but stable signal quality and sensory percepts over 14 months.

Optimal Adaptive Electrode Selection to Maximize Simultaneously Recorded Neuron Yield

This paper introduces an algorithm to optimize electrode selection in neural recordings, improving neuron isolation quality and yield compared to existing methods.

Versatile live-cell activity analysis platform for characterization of neuronal dynamics at single-cell and network level

The paper introduces a platform for label-free electrophysiological live-cell imaging of neuronal networks, demonstrating its capabilities with long-term recordings and analysis tools.

Wireless Programmable Recording and Stimulation of Deep Brain Activity in Freely Moving Humans

This paper develops a wireless platform for intracranial EEG recording and deep brain stimulation integrated with wearable technologies in freely moving humans.

A standardized head-fixation system for performing large-scale, in-vivo physiological recordings in mice

The paper describes an engineering system for standardized in vivo physiological recordings in mice, enabling large-scale, cross-platform data collection.

Learning to Control the Brain through Adaptive Closed-Loop Patterned Stimulation

This paper introduces an adaptive closed-loop stimulation system that learns to generate specific neural activity patterns in real-time.

Wireless Ensembles of Sub-mm Microimplants Communicating as a Network near 1 GHz in a Neural Application

This paper describes the design of wireless microchips for neural sensing and stimulation, demonstrating their networking capabilities in a rat model.

Low-cost and versatile electrodes for extracellular chronic recordings in rodents

The paper describes low-cost, custom-designed electrodes for chronic extracellular recordings in rodents and demonstrates their ability to record local field potentials.

Printable microscale interfaces for long-term peripheral nerve mapping and precision control

This paper introduces a microscale implantable device for long-term peripheral nerve mapping and stimulation in small animals, demonstrating stable recordings and precise modulation over multi-week periods.

CHIME: CMOS-hosted in-vivo microelectrodes for massively scalable neuronal recordings

The paper introduces CHIME, a scalable neuronal recording system using microwires and CMOS arrays to overcome limitations in capturing neural activity in mammalian brains.