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This study uses high-resolution in vivo imaging to track dynamic retinal changes in glaucoma progression across different phenotypes.

The paper characterizes Variants of Uncertain Drug Resistance (VUDRs) using quantitative measurements from clinical exposures to imatinib, identifying resistance levels and ancestry-specific variants.

This paper develops a wearable nicotine biosensor using NicA2 and CycN, achieving high sensitivity and selectivity for real-time sweat monitoring.

This paper develops a zwitterionic hydrogel-based double-network design for PEDOT:PSS that suppresses the foreign body response by 64% and improves conductivity by over one order of magnitude.

This paper develops and validates a deep learning model to automatically measure temporalis muscle thickness from CT scans, showing high correlation and accuracy compared to reference standards.

This paper introduces a dual strategy to improve antimicrobial safety by engineering conditionally-active drug conjugates and co-administering antidotes, reducing toxicity while maintaining efficacy against bacterial infections.

This study engineers AAVs targeting human carbonic anhydrase IV to enhance brain gene delivery, finding that optimized variants achieve 100-fold greater transduction than AAV9.

This study develops IL-12-loaded nanoparticles that enhance immunotherapy for metastatic ovarian cancer by promoting T cell accumulation and sensitizing tumors to checkpoint inhibitors.

This study analyzes ultrasound effects during phacoemulsification surgery, finding minimal thermal and mechanical risks and confirming tip oscillation as the primary emulsification mechanism.

The paper develops a computational platform to stabilize human VH domains for creating multispecific biologics with conditional activity.

This study identifies BACH1 as a tumor-promoting factor in hepatocellular carcinoma by activating the PI3K-AKT-mTOR pathway through PDP1 upregulation.

This study compares dual-species biofilm formation on bioengineered and natural aged dentin, showing similar biofilm patterns and viability, validating the engineered model as a reliable platform for cariogenic biofilm research.

This study generates and matures bone marrow-derived dendritic cells in vitro using STING activation to enhance CD8 T cell priming.

This study develops a copper-loaded chitosan-polyphosphate scaffold that inhibits bacterial growth, supports stem cell viability, and promotes odontogenic differentiation while being biodegradable.

The paper introduces a microfluidic device that rapidly and sensitively detects analytes at zeptomolar concentrations, enabling faster and more sensitive assays than traditional methods.

This paper introduces a graphene-based probe for high-density, long-term neuronal recording at neuronal density, demonstrating reliable signal capture and connectivity analysis in vivo.

This paper introduces PRISM, a method for high-plex spatial RNA imaging using color intensity barcodes, validated across multiple tissues and showing the role of CAFs in tumor microenvironments.

This study uses lipidomics and proteomics to analyze lipoprotein changes in coronary atherosclerosis, finding ceramide molecules are significantly associated with early stage progression.

This paper presents a computational analysis of a neural implant system for cytostatic hypothermia, showing it can achieve uniform brain cooling without overheating the body.

This study evaluates if combining antibiotics with metal ions from bioactive glasses improves antibacterial efficacy against Pseudomonas aeruginosa and Staphylococcus aureus in cystic fibrosis infections.