Discover, rate, and discuss biology preprints.

This paper develops and optimizes peptide crosslinks for hydrogels that are specifically degraded by membrane-type proteases, improving cell behavior compared to existing crosslinks.

The paper develops paralog-specific intrabodies for PSD-93 and SAP102 to study excitatory synapse organization.

The paper tests a vibro-acoustic method for tumor detection using a wavelet-based neural network, achieving 83.3% accuracy on phantom data.

This paper introduces a method for 3D multiscale analysis of joints, revealing neurovascular changes linked to pain and degeneration across species and tissues.

This paper develops an engineered PETase enzyme, DRK3, with improved thermal stability and PET degradation efficiency compared to existing enzymes.

This study improves the safety of stem cell-derived islets by enriching endocrine cells and reducing off-target cell types, enhancing long-term in vivo outcomes.

This paper develops an all-granular bioprinting system using hydrogel inks and support matrices to create complex, functional structures with cell-lined channels and soluble gradients.

This paper develops an acoustic transparency method using a chelating agent to enable functional ultrasound imaging through mouse and human skulls.

This study identifies the flexible stalk domain of sTREM2 as critical for differential ligand binding and neuroprotection in Alzheimer's disease through molecular dynamics simulations.

This paper develops an optimized R2 retroelement system for precise DNA insertion into plant genomes, achieving up to 24% efficiency for 2-5 kb payloads.

This paper develops a 3D multi-compartment assembloid that mimics human endometrial tissue and its menstrual cycle phases, enabling study of compartment-specific hormonal responses and paracrine signaling.

This study engineers bacterial extracellular contractile injection systems to deliver proteins into plant cells by targeting the FLS2 receptor, achieving efficient delivery of various cargoes.

This paper develops bio-fabricated alginate hydrogels to model prostate cancer microenvironments, showing increased cell proliferation and metastatic markers in stiffer, laminin-enriched hydrogels with cancer-associated fibroblasts.

The paper shows redox cycling enhances organic micropollutant removal by restructuring microbial metabolism and degradation pathways through co-metabolic and ROS-driven mechanisms.

This study biofabricates zonally defined meniscal grafts using inner and outer meniscus progenitor cell microtissues, showing phenotypic similarity to native meniscus.

This study demonstrates that AAV9.retro can safely and efficiently deliver genes to neuronal projections noninvasively using FUS-BBBO, offering improved specificity compared to invasive methods.

This study investigates naproxen's effects on bone quality and healing in mice, finding both COX2-dependent and -independent mechanisms with sexual dimorphism.

The paper introduces ZT Scan DIA, a metabolomics method improving annotation rates and isomer quantification in complex mixtures, with results validated in human plasma and mouse liver tissues.

This paper demonstrates a boundary-sensing mechanism in branched microtubule networks using a nanotechnology platform, showing how length-dependent branching and dynamic instability enable tunable network formation in confined spaces.

This paper develops a multiband-accelerated quantitative myocardial perfusion MRI technique to improve left ventricular coverage and provides a semi-automated framework for myocardial blood flow quantification.