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Phase-noise tolerant fully-coherent optical coherence tomography angiography for high-contrast 3D microvasculature mapping

This paper introduces a phase-noise tolerant OCTA method that improves contrast and enables 3D microvasculature mapping with high SNR correction and coherent averaging.

The "osteostat": a theory of bone mechanosensing and setpoint adaptation based on osteocytes

This paper develops a theory of bone mechanosensing and adaptation based on osteocytes, showing how setpoint adaptation during remodelling affects bone response and may lead to hysteresis.

Angiotensin (1-7)-based Proteomimetic Polymers as Topicals for the Remediation and Repair of the Cornea following Injury

This study develops a proteomimetic polymer based on angiotensin-(1-7) for topical treatment of corneal injury, showing reduced inflammation, edema, and neovascularization in a mouse model.

An L-threonine-inducible biosensor derived from the tryptophan-repressed trp promoter of Escherichia coli for high-throughput screening of L-threonine overproducers

The paper develops an L-threonine-inducible biosensor using E. coli's trp promoter for screening high-producing strains and improves ThrB variants for increased L-threonine production.

Once yearly cell-based therapy for sustained and dose tunable delivery of monoclonal antibodies

This paper develops a cell-based therapy that enables sustained, dose-tunable delivery of monoclonal antibodies through a single administration, demonstrating long-term efficacy and safety in preclinical models.

Venous Angiogenesis and Dermal Fibroblast Augmentation of Decellularized Dermis: Towards Transplantable Dermal Substitutes

This study shows that a flexible decellularized dermis can be vascularized around a single vein, with fibroblasts enhancing vascularization, and demonstrates improved vascular outcomes compared to subcutaneous implantation.

Passive Cell-Flux Partitioning Enables Single-Cell-Constrained Impedance Sensing From High-Density Microbial Cultures

This paper introduces a microfluidic chip that enables single-cell-constrained impedance sensing in high-density microbial cultures for real-time monitoring in industrial biomanufacturing.

Sensitivity of Pulmonary 4D Flow MRI Biomarkers to Controlled Spatial and Temporal Degradation in a CFD Benchmark

This paper quantifies how spatial degradation and temporal acquisition affect flow biomarkers in a CFD benchmark, showing that spatial degradation increases nRMSE while temporal acquisition impacts PI error and timing.

High-throughput microfluidic encapsulation of cells in extracellular matrix microbeads for microtissue engineering.

This paper develops a microfluidic device for high-throughput encapsulation of cells in hydrogel microbeads, achieving high cell viability and microbead stability for microtissue engineering applications.

Surfactant-Assisted Colorimetric Signal Enhancement in Paper-Based Glucose Sensing

This study identifies Tween 20 as a surfactant that enhances colorimetric glucose sensing on paper by preserving enzyme activity during drying, improving detection limits and signal stability.

Embedding wear assessment in musculoskeletal simulation: A proof-of-concept application to total hip arthroplasty

This paper presents a computational framework for embedding wear estimation in musculoskeletal simulations, demonstrating its feasibility in total hip arthroplasty.

BrightEyes-Scope: A Reference Implementation for Image Scanning Microscopy with SPAD Array Detection

BrightEyes-Scope provides a reference implementation for SPAD array-based image scanning microscopy, offering guidelines for system construction and image reconstruction to improve super-resolution imaging.

Associations of age, sex, and bicuspid aortic valve with biaxial mechanical properties and circumferential residual stress in ascending thoracic aortic aneurysm

This study examines how age, sex, and bicuspid aortic valve influence mechanical properties and residual stress in ascending thoracic aortic aneurysms.

Deep learning models detect neuromuscular disease and quantify functional impairment from video-derived biomechanics data

This paper develops deep learning models to detect neuromuscular diseases and quantify movement impairment using video-derived biomechanics data from smartphone recordings.

Spatially Tuned Localization of Interleukins and OX40 Agonists EnhancesSynergistic Anti-Tumor Immunity

This paper demonstrates that localized delivery of immunotherapeutic agents via hydrogel depots enhances synergistic anti-tumor immunity in mouse tumor models.

Investigation of Intestinal Bacteria-binding Monoclonal Antibodies Derived from Rabbit Single B Cells

This study identifies and characterizes monoclonal antibodies from rabbit B cells that bind intestinal bacteria, demonstrating their broad specificity and potential for therapeutic applications.

Patient-informed biomechanical modelling reveals mechanical mechanism of brain damage in idiopathic normal pressure hydrocephalus

This paper develops a biomechanical model of the brain to show that ventricular enlargement in iNPH causes mechanical strain in white matter, contributing to brain damage.

AMP: An Automated Marker Based Motion Capture Processing Pipeline for Kinematic Trajectory Label Scrubbing and Gaps Filling

The paper introduces AMP, an automated motion capture pipeline that reduces manual effort by 73.5% while maintaining spatial accuracy within 10 mm of manual ground truth.

Sequentially Self-Assembled Supramolecular Nanocomplexes Enable Systemic Cas9 RNP Delivery and In Vivo Tumor Genome Editing

This paper develops a supramolecular nanocomplex for systemic CRISPR-Cas9 delivery, achieving higher gene editing efficiency in tumors compared to free RNPs.

Fed-batch production of antiviral OP7 chimera defective interfering influenza A particles

This paper develops a fed-batch production process for OP7 chimera DIPs, achieving higher virus titers and bioactivity compared to batch production, with potential for GMP manufacturing.