Discover, rate, and discuss biology preprints.

This study shows zebrafish epiboly is robust to mechanical perturbations, with body axis development unaffected by induced tissue flow disruptions.

The paper uses molecular dynamics simulations to study how glycosylation affects the structure, flexibility, and neurotrophin binding of p75, TrkA, and TrkB receptors.

This paper demonstrates that RGB cameras can effectively classify up to six fluorophores in SMLM with high precision, offering a cost-effective alternative to spectral imaging.

This paper shows how ionic strength affects the structural disorder and oligomerization of the Phd transcription factor, revealing its ability to function as a conformational rheostat.

This study reveals the structural mechanism of MyD88 oligomerization in innate immune signaling using cryo-EM and high-speed AFM.

The paper investigates the long-range energy transduction mechanism in Complex I using simulations and experiments, identifying key redox-triggered coupling sites.

This study shows breast cancer cell-derived extracellular vesicles actively accelerate collagen fibrillogenesis and integrate into the matrix, influencing ECM remodeling.

The paper redesigns calmodulin to improve its function while preserving conformational dynamics, showing that structural flexibility is essential for physiological regulation.

The paper presents a workflow for 3D imaging of human mitochondria using cryo-electron tomography to study their structure under different conditions.

This study uses molecular dynamics simulations and AI/ML to elucidate how nsp10 activates nsp16's methylation function by stabilizing its SAM pocket and enabling RNA binding.

The paper shows that the mammalian heart functions as a chiral nematic field, with topological defects influencing contractile mechanics and efficiency.

This study shows that fluorescently tagged proteins in biomolecular condensates undergo crosslinking due to excitation-induced ROS, leading to condensate solidification and highlighting redox regulation of condensate properties.

This paper introduces a strategy to program tissue shape transformations through nematic organization of cellular forces, demonstrating reproducible 3D shape generation upon tissue detachment.

The paper identifies and models interactions between transactivation domains and arginine-glycine-rich regions using proteome-scale data and simulations, revealing electrostatic mechanisms driving TF-RBP coupling.

The paper introduces ioNERDSS, a Python tool that converts 3D atomic structures into coarse-grained models for simulating macromolecular self-assembly.

This study examines how individual ECM proteins affect lipid membranes structurally and mechanically, and how these effects influence cell migration.

This study demonstrates plasmonic enhancement of protein function in living cells by coupling designed nanoparticles to Archaerhodopsin proteins, increasing fluorescence and response speed.

The paper models thermal field dynamics to relate surface thermal images to in-depth freezing and thawing processes in hydrogel and tissue.

This study uses cryo-EM and solid-state NMR to determine the structure and dynamics of MscL from E. coli, revealing lipid-protein interactions that drive mechanosensitive gating.

This paper introduces VULCROM, a vacuum-free cryogenic fluorescence microscope that enables high-resolution cryo-SR-CLEM and detailed single-molecule studies in vitrified specimens.