Discover, rate, and discuss biology preprints.

This study shows that α-Synuclein's structured N-terminal domain and disordered C-terminal domain work together to enhance membrane remodeling through synergistic electrostatic and curvature effects.

This paper engineers biomimetic protein coronas on nanoparticles to improve tumor targeting and reduce immune recognition, achieving 4% ID/g tumor accumulation.

The paper investigates RNAPII clustering during ZGA in Drosophila embryos, showing clusters are stably associated with active genes and reflect transcriptional activity, not phase separation.

This study quantifies calcium-mediated fusion in giant unilamellar vesicles (GUVs) and identifies conditions under which calcium can drive full fusion without proteins.

The paper introduces a physics-based framework to convert AFM measurements into spatially resolved mechanical properties of plant cell walls, revealing how nanoscale mechanical relaxation relates to tissue-scale growth.

This paper uses visible light OCT to detect age-related changes in the RPE/BM interface in living humans, finding thickening and loss of contrast in BM and RPE+sBL associated with photoreceptor anomalies.

This study identifies that structured domains in PGL-3 drive phase separation through oligomerization and interaction with RGG motifs, independent of RNA.

The paper shows that optimal collective migration in heterogeneous tissues occurs at intermediate adhesion strength, validated through vertex models and zebrafish experiments.

The paper investigates how tau protein coordinates microtubule-actin interactions in synthetic cell-like vesicles, showing its role in MT organization and MT-actin colocalization depending on actin crosslinkers and vesicle size.

The paper uses single-molecule fluorescence microscopy to study real-time RNA folding dynamics and shows how ribosomal proteins and other factors modulate RNA conformations.

This study quantifies how nucleic acids influence liquid-liquid phase separation by analyzing oligonucleotide systems with varying properties and peptide interactions.

This study shows ComEA reversibly condenses DNA during natural transformation, first pulling DNA into the periplasm and then promoting its transport into the cytoplasm.

The paper uses molecular dynamics simulations to study how supercoiling affects DNA radiosensitivity, finding that negative supercoiling increases rupture likelihood under specific conditions.

This paper introduces Martini3-NMR, a framework that integrates NMR data into coarse-grained simulations to improve the accuracy of protein conformational ensembles.

ChironRNA resolves steric clashes and reconstructs missing atoms in RNA structures using an E(3)-equivariant diffusion model, achieving high precision on test data.

This paper introduces a physics-based simulation framework that models cell-matrix mechanotransduction and reproduces key mechanobiological behaviors without external directional cues.

This study shows that lipid membrane interfaces drive α-synuclein condensation and fibrillation at low concentrations, revealing a mechanism for its propagation in neurodegeneration.

DynMoCo identifies modular substructures in protein dynamics from molecular simulations by detecting time-evolving communities of residues.

This paper introduces a phase oscillator model to explain actomyosin oscillations, showing that cooperative behavior arises from mechanical coupling rather than molecular kinetics.

The paper develops a filament-resolved model of actin self-organization, showing how Arp2/3 and fascin concentrations determine lamellipodia, filopodia, and reticulated meshwork morphologies.