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This study identifies a calcium-mediated gating mechanism in the MthK potassium channel using solid-state NMR and MD simulations, revealing how Ca2+ blocks outward K+ flow while allowing inward flow.

This study shows that Labyrinthula species switch between network and aggregated colony morphologies based on liquid overlay presence and nutrient conditions.

The paper measures microtubule mechanics in living cells using motor-generated forces and shows that polyglutamylation increases microtubule stiffness.

This study estimates flight power in miniature wasps, finding elevated mechanical power output due to increased drag and unique wing kinematics.

The study identifies two CTCF N-terminal motifs that synergistically stall cohesin-mediated DNA loop extrusion through distinct mechanisms.

The paper develops all-optical strategies to reduce photo-bleaching in reversibly switchable fluorescent proteins, enhancing imaging resolution and duration.

This study uses atomic force microscopy to map single-cell stiffness in Xenopus laevis embryos, revealing mechanical differences between animal and vegetal hemispheres during early development.

This study determines the structure of HAstV spikes bound to FcRn, identifies conserved epitopes, and suggests repurposing FcRn inhibitors for antiviral therapy.

This study shows AlphaFold2 can learn some protein folding principles without MSAs or templates, revealing intermediate structures and a 'local first, global later' mechanism.

This study shows that target cell cortical tension determines whether macrophages trogocytose or phagocytose, with low tension favoring trogocytosis and high tension favoring phagocytosis.

The paper designs synthetic tau fibrils that mimic AD and CTE structures, showing strong seeding ability and catalytic effects in vitro and in cells.

This study shows electric fields modulate keratocyte migration speed and alignment without changing turning dynamics.

This paper introduces a microfluidic method using hyperbolic channels and 3D hydrodynamic focusing to measure cell viscoelasticity, showing it can accurately characterize mechanical properties of microgel beads and HL60 cells.

This paper shows that fluorescence excitation increases cell stiffness through reactive oxygen species production, highlighting phototoxicity and suggesting photostiffening as a tool for quantifying it.

This study uses AlphaFold2 to model multiple conformations of voltage-gated sodium channels and their interactions with protein partners, revealing structural diversity and conformational changes.

This paper uses molecular dynamics simulations to show how K+ ions rapidly dehydrate in KcsA channels through resonant tunneling, explaining their ultralow energy consumption and high flux.

The paper uses solid-state nanopore sensing to analyze conformational changes in a mutated tRNAArgUCU associated with neurodegeneration.

The paper introduces a model linking chromatin and enhancer states to transcriptional bursting dynamics, using the Monod-Wyman-Changeux framework to predict bursting behavior in C. elegans.

This paper accelerates fluorescence lifetime imaging (FLIM) using single-objective light-sheet microscopy, achieving faster and less phototoxic imaging of live multicellular systems.

This paper develops methods to control solid-liquid interface microenvironments and study bacterial surface motility using microfluidic flow cells.