Discover, rate, and discuss biology preprints.

This study shows that microbial rhodopsins can transport organic anions, expanding their known substrate range and suggesting new optogenetic applications.

The paper investigates how lever arm flexibility affects coupling to the motor domain in dimeric myosin motors using theoretical models and chimeric constructs.

The paper studies adaptive control of neural synchrony in modified FHN networks with variance-driven coupling, showing topology-dependent effects on synchrony and introducing a feedback controller for desynchronization.

The paper shows that topological defects and strings mediate ordering in endothelial cell layers, revealing an intermediate phase in their transition from disordered to ordered states.

This study investigates pulsed electric field ablation's effects on atherosclerotic plaques in rabbits, finding reduced lipid deposition, vascular remodeling, and increased elasticity.

This paper introduces a rapid high-pressure Golgi staining method for whole-brain neuronal imaging, reducing staining time from 16 days to 4 days and demonstrating applicability across multiple species.

This study evaluates an upper bound on phenotype transition probabilities using conditional complexity across various genotype-phenotype maps and finds it provides meaningful estimates.

The paper introduces META-SiM, a transformer-based model for analyzing single-molecule fluorescence microscopy data, and discovers a new intermediate state in pre-mRNA splicing.

This study develops a TRIC-based HTS platform to identify CHI3L1-targeted small molecules, finding three compounds with varying binding and inhibitory effects on CHI3L1.

This paper develops a few-shot learning framework for cryo-EM micrograph classification using triplet loss embeddings, achieving competitive performance with minimal labeled examples.

The paper develops a computational model to study how physical traits influence cell competition, finding that stiffer cells outcompete softer ones and that reduced stiffness with decreased contact inhibition creates super-competitive mutants.

This paper develops a 3D expansion microscopy toolkit to visualize and quantify nanoscale interactions in endosomes, revealing EGF and EGFR1 enrichment and Rab5a accumulation during endosomal maturation.

This study uses focal molography to measure PKA-R-cAMP interactions in buffer and serum, showing favorable binding with enthalpic dominance in serum.

The paper creates and characterizes LH2 variants in PNSB to study energy transfer dynamics and their impact on light-harvesting efficiency and bacterial fitness.

This study investigates how cardiolipin dynamics influence mitochondrial membrane remodeling via OPA1 interactions using molecular dynamics and cryoEM.

The paper experimentally shows that viral particles in evaporating respiratory droplets aggregate in protein-rich regions, outside salt crystals, and links this to internal flow dynamics.

Nano-org provides a curated resource of single-molecule localisation microscopy data for studying protein nanoscale distributions and their relationships across cell types and conditions.

The paper investigates how amino acids interact with phase-separating proteins to modulate biomolecular condensate stability and dynamics.

The paper introduces a covariance-based method to detect protein-protein attractive and repulsive interactions in molecular dynamics simulations by analyzing residue correlations.

This study uses 3D agent-based simulations to show that changes in cell motility, without chemical signaling, can recreate collective behaviors and fruiting body formation in M. xanthus colonies.