Discover, rate, and discuss biology preprints.

The paper develops a generalized kinetic model to understand how multiple actin-binding proteins regulate filament length dynamics in vivo.

This study experimentally examines how Stylonychia lemnae ciliates form feeding clusters, showing that hydrodynamic interactions enhance mixing and resource detection through collective flows.

This study uses quantitative phase microscopy to measure cellular Young's modulus in real time and finds that total variation of phase correlates with mechanical properties, revealing differences in stiffness between cell types in wound healing.

The paper introduces a multispectral imaging approach for live-cell imaging, enabling accurate unmixing of low signal-to-noise ratio data at video rates.

This paper presents a workflow for cryo-EM structure determination of small proteins using heterogeneous ab initio reconstruction, successfully solving structures of three small proteins with resolutions below 5 Å.

The paper models biomechanical feedback during zebrafish embryogenesis to predict the transition from synchronous to asynchronous cell divisions and explains the resulting cell cycle lengthening.

This study uses single-molecule force spectroscopy to reveal that CsgA exists in metastable folded states and disordered states, which are aggregation-prone and previously uncharacterized at the ensemble level.

The paper uses atomistic simulations to study voltage activation of BK channels, revealing unique VSD movement and coupling mechanisms distinct from canonical Kv channels.

This study uses 2-photon fluorescence microscopy to examine lens suture structures in wildtype and KLPH-KO mice, revealing altered suture patterns and pathological features in the knockout model.

The paper demonstrates that microtubule-based nucleation increases sensitivity to cell geometry in plant cortical arrays, leading to preferred transverse alignment in cylindrical cells.

This paper introduces AiPP, an AI-based platform for predicting ligandable sites in the human proteome, and demonstrates its application in discovering covalent inhibitors for PTPN6.

This paper introduces a 1H NMR method to enhance 13C signal detection for studying cellular metabolism in low-volume samples, demonstrating its application in tracking metabolic reactions in Clostridioides difficile.

This study uses fast MAS NMR to identify G-quartet and double-stranded structures in GGGGCC RNA aggregates linked to ALS and FTD.

This study develops a multiscale model to explore how integrin activation, clustering, and internalization influence cell-substrate adhesion dynamics and migration behavior.

The paper introduces an integrated Ising model with global inhibition to explain decision-making, showing it can improve accuracy and has unique learning properties.

This study computationally predicts and experimentally validates a vectorial hierarchy of cotranslational protein folding intermediates stabilized by non-native hydrophobic interactions.

This paper investigates how varying carotenoid conjugation lengths in bacterial LH2 complexes affect exciton dynamics and singlet-triplet annihilation, revealing that lower carotenoid triplet energy improves BChl triplet quenching.

VASAL generates realistic microvascular network phantoms and simulates dMRI signals, showing compatibility with IVIM model assumptions and vascular structure effects on diffusion.

This study shows that plectin increases fibroblast stiffness and protects against actin network disruption under compression.