Discover, rate, and discuss biology preprints.

This study uses stochastic models to analyze how genetic intra-tumour heterogeneity changes during and after treatment, finding distinct patterns in mutation frequencies and resistant clone sizes.

Shape-based fragment merging (FrankenROCS) with Thompson sampling over 22 billion molecules found neutral SARS-CoV-2 macrodomain inhibitors; analogs reached single-digit micromolar IC50, backed by 137 crystal structures.

This paper shows that residue-level fluctuations in proteins encode geometric bits communicated through sparse 3D networks of shared entropy, validated across multiple experimental data modalities.

This study links TRPM8 protein dynamics to ligand structure and cellular function using NMR, cheminformatics, and electrophysiology.

This study shows Caulobacter crescentus uses backward swimming controlled by mechanical forces to navigate confined environments.

This study models branched-cell chemotaxis in complex environments and finds that slow cells are more accurate in following weak chemoattractant signals, while neutrophils behave as fast cells compromising accuracy.

This study compares MMSA and vacuum therapy on skin explants, finding MMSA improves elasticity and collagen while reducing ROS, whereas vacuum therapy causes collagen breakdown and increased ROS.

This study develops a TRIC-based HTS platform to identify small molecule CD28 binders, finding 12 validated candidates with micromolar affinities.

This study investigates energy transfer and charge separation in the cold-adapted diatom Chaetoceros simplex using fluorescence methods, revealing larger antenna sizes and absence of red chlorophylls in PSI compared to temperate species.

This paper uses molecular dynamics simulations to show how rotation direction affects IF1's binding to ATP synthase, revealing atomic mechanisms for IF1 ejection and inhibition.

The paper introduces a model to identify decision-making classes in cell fate transitions using single-cell RNA-seq data, showing examples in lung and hematopoietic differentiation.

This study shows that Cnot4 heterozygosity reduces obesity in mice on a high-fat diet by impairing PPARγ-mediated adipocyte differentiation without affecting metabolic gene expression or serum levels.

The paper examines how chronic resistance training and acute fatigue affect passive viscoelastic properties of human skeletal muscle fibers, finding greater responsiveness in males than females.

The paper identifies a novel subclass of MgtE Mg2+ channels and demonstrates that de novo protein design can stabilize and enable structural analysis of otherwise unstable homologs.

This study shows that substrate elasticity affects the motility cycle and shape of chicken cardiac fibroblasts, with soft substrates causing slower retraction and more oscillatory movement.

This paper investigates how temozolomide crosses brain plasma membranes using molecular dynamics simulations, finding that it cannot cross by pure diffusion at normal body temperature but requires higher temperatures or assistance from cholesterol and cerebroside lipids.

This paper investigates how Trikafta corrects F508del-CFTR by altering phosphorylation-dependent interactions between transmembrane and nucleotide-binding domains, stabilizing NBD1 above body temperature.

This paper observes conformational dynamics of unmodified IDPs/IDRs at the single-molecule level using nanoaperture optical tweezers, revealing increased conformational variation and phosphorylation-induced compaction.

The paper reports NMR resonance assignments for EmrE, a multidrug transporter, using solution and solid-state NMR techniques at specific pH conditions.

This study shows that phosphorylation enables distinct nucleation mechanisms for NSP5 condensate formation in rotaviruses, depending on strain-specific LLPS propensity.