Discover, rate, and discuss biology preprints.

The paper shows spatial structure in bacterial populations increases the probability of evolutionary rescue by antibiotic resistance through enhanced fixation of resistant mutants in small subpopulations.

This paper introduces a deep learning-powered colloidal digital SERS platform for precise monitoring of cell culture media, achieving high accuracy and reproducibility in detecting analytes.

The paper designs antigens that present a tumor-specific cryptic epitope in the conformation recognized by mAb806, showing successful stabilization of the epitope in vitro.

This study reveals the conformational dynamics of the Cas8 protein in the Cascade-TniQ complex, showing how it transitions between open and closed states to facilitate DNA binding and transposition.

This study shows that bacterial migration direction in oxygen gradients depends on population density, revealing a critical density threshold for collective migration.

This study investigates KCNJ2 mutations linked to ventricular arrhythmia using computational modeling and functional analysis, revealing mutation-specific structural perturbations and their impact on channel stability.

The paper uses Bayesian nonparametric methods to analyze residence times of cholesterol interactions with GPCRs in MD simulations, revealing kinetic rates and molecular events.

This study uses 3D reconstructions and simulations to show that geometrical ratcheting stabilizes the shape of budding intestinal organoids through changes in tension and actomyosin reorganization.

This study examines the relationship between turbulence and the soundscape of intertidal oyster reefs, finding that turbulence and sound may attract larvae in complementary ways.

This study examines how continuous input of organic fertilizer and biochar affects soil carbon components, aggregate stability, and carbon pool characteristics in vegetable fields, finding that their combined use synergistically enhances carbon sequestration and soil fertility.

This paper analyzes gauge freedoms in sequence-function models and shows their relationship to symmetry and parameter interpretability.

This study quantifies morphological and mechanical changes in endothelial cells infected with KSHV, identifying potential diagnostic and therapeutic markers.

This paper introduces a spatial stochastic model of nuclear mRNA with telegraph transcriptional dynamics and shows it can be approximated by a Poisson-Beta distribution for efficient parameter inference.

This study demonstrates how oriented cell arrangements can drive controlled shape transformations in reconstituted matrices through directed forces and anisotropic remodeling.

The paper introduces a metric for measuring accumulated neurotoxicity of alpha-synuclein oligomers and finds that rapid fibril formation reduces toxicity, while impaired degradation increases it.

The paper introduces a synthetic potassium channel that senses and mitigates oxidative stress by modulating membrane potential in cells and organelles.

This study identifies how the A82V mutation in Ebola virus GP enhances membrane fusion through conformational changes, using simulations and experiments.

This study introduces pc-SMdM, a super-resolution technique to map nanoscale diffusivity on cellular membranes, revealing clusters influenced by cholesterol and membrane structure.

This study shows BicD and MAP7 work together to activate Drosophila kinesin-1 through distinct mechanisms, enhancing motor activity and microtubule engagement.

This study shows that PIP2-Tmie interactions, not myosin motors, drive slow adaptation in mammalian hair cells, as demonstrated by rescue experiments and disruption studies.