Discover, rate, and discuss biology preprints.

The paper shows LC3B forms nanoclusters on autophagosomes via specific lipid interactions and a unique binding pocket, impacting autophagosome motility.

The paper develops a simulation framework to infer nucleosome-resolution chromatin structures from RCMC data, revealing euchromatin as condensed domains with accessible promoter/enhancer regions.

This paper uses third-harmonic generation microscopy to visualize and measure mucociliary transport in human airway epithelium models without staining or processing.

This study improves molecular dynamics models to better predict nanopore blockade currents from single-stranded DNA by refining force field parameters.

This study models oscillatory and steady streaming flow of cerebrospinal fluid in the cranial subarachnoid space using a lubrication-based framework, showing that oscillatory forcing enhances solute transport.

The paper introduces an optical imaging method to precisely monitor receptor-arrestin interactions in live cells, showing arrestin redistribution upon receptor activation.

This study investigates the rotational mechanism of the bacterial flagellar motor by analyzing protonation dynamics and structural asymmetry in CjMotAB using cryo-EM and computational methods.

This study quantifies how α-Synuclein monomers and seeds affect the material properties of Tau condensates, showing distinct effects on viscosity and interfacial tension.

This paper provides a framework for measuring protein oligomerization equilibria using fluorescence correlation spectroscopy, demonstrating its application with PCNA under varying ionic strength conditions.

This study uses cryo-EM to reveal how calcium binding to connexin-46/50 gap junctions induces structural changes leading to pore collapse and gating.

This study quantifies spatio-temporal image degradation from motion blur in fluorescence microscopy using SSNR and simulations, showing resolution loss up to 40% for 90-degree motion direction changes.

This study determines the structural basis of SAMD9 autoinhibition and explains how pathogenic mutations disrupt this mechanism to cause disease.

The paper shows that cell division in epithelia follows a mechanical principal-stress rule rather than a geometric rule, as cells divide along their principal stress axis to relieve anisotropic stress.

msaGUI is a no-code tool for analyzing and visualizing multispectral images through customizable workflows and exportable outputs.

This study shows that two point mutations at the same residue in beta-myosin heavy chain cause distinct cardiomyopathies through different molecular mechanisms.

The paper examines protein adsorption to DNA-wrapped SWCNTs by measuring photoluminescence changes, identifying metalloproteins as more effective quenchers than metal-free proteins.

This study investigates how saponin chemistry affects bicelle properties like anionic lipid tolerance and divalent metal ion stability, identifying design principles for better membrane-mimetic systems.

This study investigates how linker histone H1.0 binds to nucleosomes and DNA, revealing multiple pathways facilitated by histone chaperones like Nap1.

This study investigates how BMP deficiency in Batten disease leads to lysosomal accumulation of ATP synthase c-rings through molecular simulations showing BMP's preferential interaction with the c-ring.

The paper uses Hi-D to track chromatin motion in live human cells and finds that DNA content doubling, not cohesin, reduces chromatin mobility during the cell cycle.