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The paper introduces a method to predict the direction of phenotypic differences between individuals using genomic data, achieving over 90% accuracy in many cases.

This study shows that PD-L1 from retinal pigment epithelium reprograms microglia to reduce inflammation and protect against retinal degeneration in mouse models.

The paper identifies two functional domains in a genomic region that influence adult migration timing in Chinook salmon, showing how a simple genetic system interacts with genomic backgrounds to generate ecotypic diversity.

The paper identifies genetic determinants of CD8+ T cell receptor (TCR) repertoire in cancer patients before and after immune checkpoint blockade (ICB) treatment, finding associations with HLA alleles and treatment response.

The paper shows eIF4E and NCBP2 have distinct roles in nuclear mRNA processing, influencing different transcript populations and outcomes.

The paper shows that mutations in the CerS homeodomain can either worsen or improve insulin resistance in Drosophila under high sugar diet conditions.

This study identifies nervous system requirements for Alzheimer's disease risk genes in Drosophila by analyzing gene function and neurodegeneration.

The paper identifies 63 active and 34 putative inactive introns in Trichomonas vaginalis using a new assembly and pipeline, and compares them to its close relative Trichomonas stableri.

This study crosses elite maize inbred lines with wild relatives to enhance genetic diversity, identifying crosses with significant yield improvements and genetic introgression.

This study identifies genetic variants and genes associated with diapause in Drosophila, linking them to olfactory and reproductive systems.

This study uses whole-genome sequencing and genomic prediction to accelerate heartwood formation in oak trees by identifying genetic markers linked to heartwood traits.

This study shows that asp and Sas4 genes in Drosophila affect nuclear structure, chromatin organization, and genome stability, contributing to microcephaly pathogenesis.

Missense3D-PTMdb maps missense variants and PTM sites to AlphaFold 3D models to explore their structural and functional impacts.

This paper extends phase-type theory to time-inhomogeneous coalescent processes, enabling exact computation of moments under diverse demographic scenarios and introduces a software package for parameter estimation.

This paper introduces an expectation-maximization method to infer general diploid selection from time-series genetic data, finding evidence for selection in six genomic regions from ancient DNA samples.

This paper describes a pig model of Angelman syndrome that mirrors early developmental symptoms observed in humans.

The paper identifies characteristics of TP53 variants with reduced penetrance using ClinVar data and a random forest model, finding they have intermediate function, higher frequency, and delayed disease onset.

This paper introduces as-eGRM, a method to reveal ancestry-specific structures in admixed populations by incorporating genealogical trees and local ancestry calls, outperforming existing methods in simulated and empirical datasets.

The paper estimates the probability of finding Y-STR profile matches and related individuals in forensic databases using simulation studies.

This study uses CRISPR/Cas9 to knockout Laccase2 in pea aphids, revealing its essential role in eggshell pigmentation, hardening, and survival during overwintering diapause.