Author

Shabab B. Hannan

Baylor College of MedicineORCID 0000-0002-8984-4773Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:Drosophila· 3 Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Oguz KancaiD· 2 shared Ann-Christin Krahl· 1 shared Anna Iatroudi· 1 shared Barbara Gailer· 1 shared Chad A. ShawiD· 1 shared Christopher J. H. ElliottiD· 1 shared Colleen E StrohleiniD· 1 shared Hugo Jozef BelleniD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersGenetics

Oguz KancaORCID

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4 papers

Recent·Most cited

NLGN3 autism variants have distinct functional impact on synapses and sleep behavior in Drosophila

Rebekah E. Townsley, Jonathan C. Andrews, Saurabh Srivastav, Sharayu V. Jangam, Shabab B. Hannan, Oguz Kanca, Shinya Yamamoto, Michael F. Wangler

This study investigates the functional impact of different NLGN3 variants in Drosophila, finding distinct effects on synapse morphology, sleep behavior, and vesicle dynamics.

bioRxiv · Mar 30, 2026 · PreprintGenetics

Revealing the nervous system requirements of Alzheimer disease risk genes in Drosophila

Jennifer Deger, Shabab B. Hannan, Mingxue Gu, Colleen E Strohlein, Lindsey D. Goodman, Sasidhar Pasupuleti, Zahid Shaik, Liwen Ma, Yarong Li, Jiayang Li, Morgan C Stephens, Michal Tyrlík, Zhandong Liu, Ismael Al‐Ramahi, Juan Botas, , Joshua M Shulman

This study identifies nervous system requirements for Alzheimer's disease risk genes in Drosophila by analyzing gene function and neurodegeneration.

bioRxiv · Jul 24, 2025 · PreprintGenetics

A retrograde transit filter mediated by optineurin controls mitostasis in distal axons

Natalia A. Marahori, Barbara Gailer, Martina Schifferer, Tatjana Kleele, Anna Iatroudi, Shabab B. Hannan, Petros Avramopoulos, Stefan Hanns Engelhardt, Melike Lakadamyali, Monika S. Brill, Thomas Misgeld

The paper identifies a retrograde transit filter in distal axons mediated by optineurin that regulates mitochondrial homeostasis, independent of PINK1 and parkin.

bioRxiv · Jul 28, 2024 · PreprintCell Biology

Autophagy inhibition rescues structural and functional defects caused by the loss of mitochondrial chaperone Hsc70-5/mortalin in Drosophila

Jun‐yi Zhu, Shabab B. Hannan, Nina M. Dräger, Natalia Vereshchagina, Ann-Christin Krahl, Yulong Fu, Christopher J. H. Elliott, Zhe Han, Thomas Robert Jahn, Tobias M. Rasse

The paper investigates the role of Hsc70-5/mortalin loss in Drosophila Parkinson disease models and shows that autophagy inhibition rescues multiple phenotypes.

Autophagy · Jan 6, 2021Peer-reviewedGenetics