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The paper successfully delivers CRISPR-Cas9 via a baculovirus vector to knock down AmOctβ2R in honey bee brain neurons, leading to appetite suppression.

The paper investigates how DNA repair genes influence Cas9-induced mutations by analyzing mutational outcomes across 2,838 synthetic targets in mouse cells, revealing gene-specific roles and improving predictive models.

The paper presents a Cas12a-based system using multiplexed sgRNAs to achieve efficient and specific gene knockouts in Drosophila with minimal off-target effects.

The paper identifies DOA/CLK2 as a kinase that phosphorylates Fl(2)d/WTAP to enhance m6A methyltransferase complex activity, crucial for dosage compensation and splicing regulation.

The paper investigates RNA modifications in the amphibious plant Riccia fluitans under different environments, finding correlations between modification types and transcript features.

This study identifies QTLs associated with freezing tolerance in winter faba bean using GWAS, providing genomic targets for marker-assisted breeding.

The paper shows that lack of PER in Drosophila leads to genotoxic stress in neuronal progenitors during development.

The paper identifies a gene regulatory network controlled by SNORD116 snoRNAs and predicts their targets in Prader-Willi syndrome using isogenic cell lines and computational analysis.

The paper reports on a competition to predict maize yield using genetic and environmental data, showing that diverse modeling approaches can achieve good results.

The paper identifies a negatively-charged region in CTCF's C-terminal domain that weakens DNA binding and chromatin accessibility through an autoinhibitory mechanism.

This paper develops unbiased method-of-moments estimators for hierarchical F-statistics tailored for Pool-Seq data and validates them using simulations and real Drosophila data.

This study identifies Imp's role in preventing seizures by regulating Syndecan mRNA in Drosophila neurons, showing that Imp loss leads to seizure behavior through Sdc dysfunction.

The paper presents split-Gal4 driver lines targeting conserved signaling ligands in Drosophila to identify cells co-expressing pairs of ligands.

The paper develops a high-throughput method to identify essential and dispensable domains in AcrIIA4 by generating and testing precise deletions, revealing that PAM binding inhibition is key while catalytic domain interaction is dispensable.

The paper identifies differentially expressed keratin and keratin-associated proteins in mutant mice with hair loss, linking them to hair follicle formation defects.

The paper shows ancestry-specific gene expression in monocytes mediates neurodegenerative disease risk through innate immune cell expression of neurodegeneration-related genes.

The paper identifies a new cancer-testis long noncoding RNA, OTP-AS1, which is antisense to the OTP gene and may regulate its expression in tumors.

This paper introduces a Bayesian Hierarchical Hypothesis Testing method for GWAS that improves power and fine-mapping resolution, leading to more discoveries in serum urate risk variant mapping.

NAMERS provides a curated DNA sequence database to improve eDNA metabarcoding workflows by offering high-quality reference sequences for freshwater fish in British Columbia.