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This study evaluates the efficiency and resistance allele formation of two CRISPR/Cas9-based gene drives in Aedes aegypti, finding one drive achieves super-Mendelian inheritance rates.

The paper introduces two LD estimation algorithms to create high-resolution LD grids across species, revealing evolutionary patterns and population structure.

PSAP-genomic-regions improves variant prioritization in whole genome sequencing by incorporating functional genomic regions, enhancing detection of both coding and non-coding pathogenic variants in rare disease diagnosis.

This study performs a genome-wide association analysis to identify genetic loci influencing flowering date in cultivated olive trees using capture sequencing data from 318 genotypes.

The paper identifies Cadherin 16 as a regulator of sensory gating in zebrafish via the corpuscle of Stannius, showing its role in calcium homeostasis and behavior.

This paper investigates the role of the Drosophila ABCD1 ortholog in peroxisomal dynamics and shows that human ABCD1 overexpression inhibits peroxisomal biogenesis.

This paper measures aneuploidy reversion rates in yeast using a fluctuation assay, showing fitness effects influence estimates and chromosome-specific loss rates.

CAL-Leiden is a co-segregation model for BRCA1, BRCA2, and PALB2 variant classification, integrating population data and cancer types to improve pathogenicity assessment.

This paper identifies a cytochrome P450 gene variant that contributes to benzimidazole resistance in nematodes, independent of beta-tubulin mutations.

The paper analyzes maternal genetic diversity in the Konkani population of India using mitogenomes, revealing distinct haplogroups and historical migration patterns.

This study examines the effects of two mistranslating tRNA variants in Drosophila melanogaster, showing sex-specific impacts on development, lifespan, and locomotion.

This paper introduces a new family of five-leaf admixture tests called {Delta}-statistics to better determine the directionality of admixture compared to existing methods like DFOIL.

The paper identifies genes responsible for metabolic dysfunction-associated steatohepatitis using single-cell eQTL analysis in liver biopsies from MASLD patients and controls.

This paper estimates dominance and selection parameters for nonsynonymous mutations in humans using site frequency spectra and explores their implications for genetic load and inbreeding depression.

This paper demonstrates that simultaneous silencing of intestinal nucleases and a vital gene via dsRNA feeding significantly improves RNAi efficiency and mortality in Mediterranean fruit fly adults.

This study investigates insecticide resistance in Myzus persicae by comparing sensitivity of specific genotypes to various insecticides and screening for resistance mutations.

The paper generates a proteogenomic atlas of the human neural retina using long-read RNA-sequencing and mass spectrometry, identifying novel transcript isoforms and peptides.

The paper analyzes transcriptomic differences in human brain cells with nine high-risk neuropsychiatric CNVs compared to non-carriers, finding widespread gene expression disruptions and shared functional pathways.

The paper identifies a novel OsIAA3-OsARF16-OsBUL1 module that regulates grain size in rice by modulating cell expansion and proliferation.

The paper identifies Skp1 as a conserved structural component of the meiotic synaptonemal complex in nematodes, showing its role in SC assembly and fertility.