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This study introduces a novel GxE PRS model that improves type 1 error control and statistical power for genetic risk prediction, with applications to quantitative and binary traits.

This study shows that Tbx1 haploinsufficiency in mice causes brain metabolic and behavioral issues, which are partially reversed by vitamin B12 treatment.

The paper investigates cis-regulatory evolution on the Y chromosome of threespine stickleback, finding positive selection in enhancer regions and correlation with X-biased gametolog expression.

The paper develops a sex-sorting technique for insects using fluorescent proteins and differential splicing in Drosophila melanogaster.

This study introduces RVMMAT, a method for detecting time-varying genetic effects on longitudinal binary traits, and applies it to identify hypertension-associated loci.

The paper estimates genetic gains in IRRIs rice salinity breeding programs and develops an elite breeding panel to improve future breeding strategies for salinity-tolerant high-yielding rice lines.

The paper uses Duplex Sequencing to measure somatic mutation rates in Arabidopsis under different temperatures, finding very low mutation frequencies in wild-type plants.

This paper uses machine learning to predict soybean grain yield under different shading levels, finding plant height as the most predictive trait.

The paper identifies and validates splicing variants in the DMD gene, showing most intronic variants affect splicing and many exonic variants disrupt splicing, with clinical implications for Duchenne and Becker muscular dystrophy.

This study investigates the role of SCC3 in rice mitosis and meiosis, showing its essential function in homologous chromosome pairing and synapsis.

The paper shows heat stress disrupts heterochromatin stability at the mat locus in fission yeast by altering Atf1 phosphorylation and its interaction with Swi6HP1.

This study shows that DNMT3B PWWP mutations cause hypermethylation of heterochromatin marked by H3K9me3, disrupting DNA methylation homeostasis and contributing to ICF syndrome, cancer, and aging.

The paper shows that the synthetic growth defect in a dbp1 deletion mutant is due to loss of Dbp1, not reduced MRP51 expression from the hphMX6 marker.

This paper compares methods for detecting genetic variants affecting phenotypic variance under gene-environment interactions and identifies optimal approaches for different exposure types.

The paper reanalyzes a GWAS to show that a single locus on chromosome 3 determines praziquantel response in Schistosoma mansoni, rather than two loci.

The paper identifies LG4 enhancers that physically interact with gene promoters via G4:G4 DNA structures and links SNPs in these enhancers to CF lung disease severity.

This study investigates how hybridisation in Saccharomyces species affects antifungal drug resistance by identifying QTLs and potential causal genes involved in resistance to fluconazole, micafungin, and flucytosine.

The paper assesses the effects of acute temperature changes on Atlantic salmon health and survival, finding significant impacts on growth, survival, and maturation, and suggests genetic mitigation potential.

The paper uses a crop model to show that breeding sorghum for limited transpiration could increase yield in drought-prone US regions without tradeoffs.