Discover, rate, and discuss biology preprints.

The paper systematically explores genetic variants in human PKR and vaccinia virus K3 to understand their evolutionary dynamics and functional interactions.

This study identifies genomic variations and candidate genes affecting growth in large yellow croaker using whole genome resequencing and GWAS.

The paper evaluates models to estimate genetic gain in soybean seed yield from multi-environment trials and finds all models are biased, recommending multiple models for accurate estimation.

The paper investigates satDNA evolution in Nothobranchius killifishes, identifying centromere-associated repeats and suggesting centromere drive and spindle polarity reversal as factors in karyotype change.

This study identifies how Mec1/ATR kinase controls homologous recombination to suppress gross chromosomal rearrangements through Rad53 and Sgs1 pathways.

The paper investigates the role of BBS1 in suppressing mesenchymal cell identities in epithelial cells, showing clonal variability and dysregulation of EMT genes across tissues.

This study characterizes genomic and phenotypic variation in finger millet using SNP and trait data, revealing complex diversification patterns and geographic differentiation.

This study shows that catalytic activity of Bin3 is not required for 7SK snRNP function in Drosophila, as catalytic mutants can rescue all phenotypes.

The paper shows that linc-133 gain of function compensates for daf-18 loss by restoring survival in C. elegans through protein homeostasis mechanisms.

This study simulates dairy cattle breeding programs to assess how accounting for mitochondrial DNA variation affects the accuracy of breeding values and genetic gain.

This paper introduces Indirect GWAS, a method that accelerates biobank-scale GWAS by computing statistics for custom phenotypes using summary statistics, reducing runtime significantly.

This study develops a mouse model of ZTTK syndrome by creating Son haploinsufficiency mice, revealing critical roles of SON in organ development and hematopoiesis.

The paper identifies cell morphology quantitative trait loci (cmQTL) in fibroblasts exposed to arsenic, revealing gene-environment interactions and genetic regulation of oxidative stress responses.

This study investigates the role of the ANKRD31-REC114 interaction in meiotic recombination and spermatogenesis, showing its critical importance for DSB formation, repair, and location in mice.

The paper assesses runs of homozygosity (ROH) in Sahiwal cattle to evaluate autozygosity, inbreeding, and candidate genes related to milk production.

The paper edits ω- and γ-gliadin gene clusters in wheat using CRISPR-Cas9 to reduce immunoreactivity without affecting protein quality.

The paper quantifies Prdm9-independent recombination hotspots in 52 mammals, finding that these hotspots are common and often coexist with Prdm9-directed hotspots.

The paper generates a mouse model with an in-frame deletion of exons 52-55 in Dmd, mimicking Becker Muscular Dystrophy, and characterizes its long-term effects on muscle and heart function.