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Epigenetic maintenance of PRC2-repressed chromatin requires RTT109 but not H3K56 acetylation

The paper identifies RTT109 as essential for maintaining PRC2-repressed chromatin in Neurospora crassa, showing it is required for epigenetic memory but not H3K56 acetylation.

Selection on cuticle color produces a genome-wide response that does not localize to known major genes in Drosophila

The paper shows that selection on cuticle color in Drosophila leads to genome-wide allele frequency shifts, not localized to major genes, and identifies a technical artifact in pool-seq studies.

A new mouse model for a high-risk AMD variant, ARMS2A69S

This paper creates a mouse model with the ARMS2A69S variant to study AMD, finding it causes mitochondrial dysfunction and AMD-like phenotypes.

Adaptive introgression in subdivided populations leaves distinct genomic footprints under global and local selection: a case study in Ciona intestinalis

The paper investigates adaptive introgression in subdivided populations, finding no correlation between adaptive allele frequency and introgressed tract length, suggesting local adaptation rather than a traveling wave.

Developmental Convergence Across Diverse Genetic Architectures in Childhood Apraxia of Speech

The paper identifies multiple genetic variants associated with childhood apraxia of speech through whole-exome sequencing and functional analysis, proposing four novel candidate genes.

Significance filtering induces denominator selection bias in local genetic correlation: closed-form characterisation, a gate-aware correction, and an applicability diagnostic

The paper identifies a bias in local genetic correlation estimation due to significance filtering and proposes a correction method with a diagnostic tool.

Bone response to intermittent parathyroid hormone (PTH) is both genetic and sex specific

This study investigates genetic and sex-specific factors influencing bone response to PTH in mice, finding strong heritability and sex-dependent mechanisms.

The effects of hitchhiking and repulsion of deleterious alleles on linkage disequilibrium during a selective sweep

The paper uses simulations to study how hitchhiking and repulsion of deleterious alleles affect linkage disequilibrium during selective sweeps, finding criss-crossing patterns and exceptions in empirical data.

The ortholog of the Human T2D Risk Gene STEAP2 is Required for Glucose Stimulated Insulin Secretion in Mice

This study shows that Steap2 is essential for glucose-stimulated insulin secretion in mice by maintaining mitochondrial function in pancreatic beta-cells.

GWAS of flag leaf primary metabolites uncovers metabolic QTL hubs linked to grain yield stability under drought in field-grown indica rice

This study identifies metabolic QTL hubs in indica rice linked to grain yield stability under drought by analyzing metabolomics and GWAS data from field-grown plants.

Voluntary Exercise Differentially Affects High-Fat Induced Metabolic Phenotypes Across BXD Mouse Strains

The paper shows that voluntary exercise improves glucose tolerance in some BXD mouse strains on a high-fat diet, independent of caloric intake, and suggests gut microbiota may mediate this effect.

Mutation choice biases the structure of empirical fitness landscapes

The paper examines how mutation selection biases affect fitness landscape statistics in random models and real datasets, showing inflated variance and altered local maxima under adaptive trajectory mutations.

snpXplorer: haplotype-block representation of GWAS signals for integrated variant and cross-trait interpretation

In which cases does it make sense to classify an individual into one population and what are the alternatives?

The paper evaluates methods to classify individuals into populations using ancestry informative markers, finding a naive Bayes classifier performs best in identifying out-of-reference individuals.

LoGicAl: Local ancestry and genotype calling uncertainty-aware ancestry-specific allele frequency estimation from admixed samples

LoGicAl estimates ancestry-specific allele frequencies from admixed samples by accounting for uncertainty in local ancestry and genotype calling, improving accuracy and scalability.

A genetic screen to identify novel interactions of the phosphatidylinositol phosphate signaling pathway in Drosophila spermatogenesis

The paper identifies genetic interactions of the phosphatidylinositol phosphate signaling pathway in Drosophila spermatogenesis through a sensitized genetic screen.

Deciphering the genetic basis of phytoplankton traits through genome-wide association studies

This study uses GWAS to identify genetic loci associated with pigment and lipid metabolism in the microalga Tisochrysis lutea, revealing previously unknown genomic regions linked to these traits.

Genetic backgrounds and sex modulate indirect genetic effects of Epha4 in laboratory mice

This study shows that genetic background and sex influence the indirect genetic effects of Epha4 in mice, revealing context-dependent social epistasis.

A massively parallel reporter assay of MECP2 cis-regulatory elements reveals genetic candidates for male-biased autism

The paper identifies noncoding MECP2 variants that cause male-biased autism by disrupting CRE activity and reducing MECP2 expression.

The genomic complexity of invasion: cryptic lineages, founder effects, and polygenic sex determination in armored catfish

The paper evaluates biocontrol feasibility in invasive armored catfish by analyzing genomic diversity, population structure, and sex determination mechanisms.