This paper expands the RatGTEx resource with transcriptome-wide associations across 3,160 RNA-seq samples, identifying 7,473 gene-trait links and 144,876 QTLs for 22,599 genes.

bioRxiv · Nov 6, 2026 · PreprintGenetics

Bone response to intermittent parathyroid hormone (PTH) is both genetic and sex specific

Douglas J. Adams, Dana A. Godfrey, SHANE E. RIDOUX, Robert D. Maynard, Nicole S. Szeto, Ethan M. Lange, Cheryl L. Ackert‐Bicknell

This study investigates genetic and sex-specific factors influencing bone response to PTH in mice, finding strong heritability and sex-dependent mechanisms.

Bone · Oct 3, 2026Peer-reviewedGenetics

Y and Mitochondrial Chromosomes in the Heterogeneous Stock Rat Population

Faith Okamoto, Apurva S. Chitre, Thiago Missfeldt Sanches, Denghui Chen, Daniel B. Munro, Allegra T. Aron, Angela Beeson, Hannah V. Bimschleger, Maya Eid, Angel Garcia Martinez, Wenyan Han, Katie Holl, Tyler Jackson, Benjamin B. Johnson, Christopher P. King, , Abraham A. Palmer

The paper genotypes Y and mitochondrial chromosomes in heterogeneous stock rats and finds no significant associations with complex traits, except for gene expression on these chromosomes.

G3 Genes Genomes Genetics · Sep 5, 2024Peer-reviewedBioinformatics

An Atlas of Human and Murine Genetic Influences on Osteoporosis

John A. Morris, John P. Kemp, Scott E. Youlten, Laetitia Laurent, John G. Logan, Ryan Chau Chia Chai, Nicholas A. Vulpescu, Vincenzo Forgetta, Aaron Kleinman, Sindhu T. Mohanty, C. Marcelo Sergio, Julian M.W. Quinn, Loan Nguyen‐Yamamoto, Aimée-Lee Luco, Jinchu Vijay, , John Brent Richards

This paper identifies 518 genetic loci associated with bone mineral density and fracture risk, validates causal genes in mice, and provides insights for osteoporosis drug development.

Nature Genetics · Dec 17, 2018Peer-reviewedGenomics