Discover, rate, and discuss biology preprints.

The paper identifies a single Indian bekang strain with a conserved accessory gene profile similar to the Japanese natto clade, suggesting a shared adaptive strategy despite phylogenetic divergence.

SEQURNA improves gene detection in FLASH-seq compared to commercial inhibitors and eliminates the need for DTT, enhancing data quality and reducing costs.

This paper introduces NoLMseq, a method to map nucleolar-associated domains (NADs) in single cells, revealing their heterogeneity and response to nucleolar stress.

The paper integrates 4D Nucleome data to analyze 3D genome structure and function in human cells, revealing chromatin domains, loops, and interactions, and showing how genetic variants affect genome folding.

The paper investigates dosage compensation in the eastern three-lined skink, finding that X chromosome expression in sex-reversed individuals matches their genotype rather than phenotype.

The paper integrates enhancer-promoter interactions and RNA-DNA contacts to show RNA's role in modulating cis-regulatory networks during neural differentiation.

This study sequences the complete mitochondrial genomes of two Nephtheidae species, confirming their gene arrangement and phylogenetic placement within the family.

The paper characterizes the binding and functional landscape of NHR-25, a nuclear hormone receptor in C. elegans, revealing two binding modes and the role of a single response element in regulating gene expression.

This paper presents a near-complete lamprey genome assembly, revealing gene family expansions and regulatory elements linked to vertebrate innovations.

This study uses single-cell and spatial profiling to identify cellular and molecular drivers of beta cell dysfunction in the pancreas of cystic fibrosis patients.

The paper presents T2T reference genomes from a multi-generational pedigree to study genetic and epigenetic inheritance across the complete genome.

This study analyzes eight high-coverage Jomon genomes to reveal genetic continuity and phenotypic traits of ancient Japanese hunter-gatherers, showing their genetic influence on present-day Japanese populations.

This paper introduces a pooled CRISPR screening platform combined with self-supervised deep learning to infer gene function from morphological phenotypes without target-specific biomarkers.

The paper identifies trans-acting genetic variation that regulates 3D chromatin interactions through heterochromatin formation, showing how this mechanism coordinates chromatin state and gene expression changes.

This study evaluates how admixture, selection, and demographic history influence GWAS power and fine-mapping precision in admixed populations using simulations and empirical data.

The paper uses single-cell multiomics to study B cell changes in mice during malaria reinfection, finding shifts in memory B cell composition and epigenetic programs linked to rapid antibody production.

The paper investigates why many GWAS loci linked to immune-mediated diseases lack eQTL colocalization by analyzing chromatin accessibility QTLs in LCLs and other immune cell types.

This study uses transcriptomic profiling and machine learning to uncover regulatory complexity in mitochondrial gene expression in severe Plasmodium vivax malaria, highlighting the role of natural antisense transcripts.

This study benchmarks six duplex sequencing technologies to evaluate their performance in detecting somatic mutations across different genomic contexts and tissue types.

The paper provides the first direct evidence of transcription from germline-restricted chromosomes (GRCs) in fungus gnats, identifying expressed genes and a horizontally acquired bacterial region.