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This study examines how dietary fat affects gene expression in five tissues and phenotypes of desert-adapted cactus mice, revealing impacts on immune function, circadian regulation, and mitochondrial function.

The paper shows that DNA methylation ageing is reflected in correlations between genomic loci, with a preference for 500 bp apart sites, and links this to PRC2-dependent H3K27me3 dilution.

This study uses whole-genome sequencing to show that LINE-1 retrotransposition directly causes chromosomal rearrangements and instability in cancer genomes.

The paper shows that Lefty1 and Lefty2 genes in mouse embryonic stem cells are regulated by separate enhancers despite being in the same TAD.

The paper presents a genomic data resource from a caloric restriction trial, including SNP genotypes and multi-omic longitudinal data from multiple tissues.

This study reports the emergence of Candida auris in Brazil using genomic surveillance to identify clade IV isolates, potential Colombian introduction, and azole resistance mutations.

The paper compares genomic diversity, inbreeding, and genetic load between insular and mainland populations of three West African primates, finding lower diversity and higher inbreeding in island populations but no evidence of increased deleterious variation.

The paper investigates how extrachromosomal DNA (eccDNA) contributes to glufosinate resistance in Palmer amaranth by amplifying the GS2 gene.

This study creates a comprehensive epigenomic atlas of turbot embryogenesis, revealing chromatin dynamics and regulatory elements important for development and aquaculture.

This paper compares how GWAS and rare variant burden tests prioritize genes for 209 traits in the UK Biobank, showing they focus on different genes due to distinct prioritization criteria.

This study shows that within-family GWAS does not improve prediction accuracy in admixed populations, suggesting genetic architecture differences, not confounding factors, drive the decline in polygenic index performance.

The paper maps tissue-specific mtDNA heteroplasmy and its associations with age and mtDNA gene expression using bulk RNAseq data from GTEx.

The paper introduces a network-based method to analyze human genetic variation beyond continental groups, revealing complex relationships and challenging traditional clustering approaches.

The paper identifies human divergently-paired genes (DPGs) and analyzes their conservation, regulatory features, and evolutionary patterns across vertebrate lineages.

The paper identifies distinct gut microbiome signatures during acute SARS-CoV-2 infection that predict long COVID, showing microbiome profiles better predict risk than clinical variables.

The paper compares transcriptome responses of four coral species to acute heat stress, finding differences in stress response gene abundance and activation patterns that correlate with thermal tolerance.

This study uses machine learning to improve antimicrobial resistance prediction in Klebsiella pneumoniae for antibiotics where rule-based methods fail, identifying new resistance determinants.

This paper introduces LSV-seq, a targeted RNA-seq method optimized with machine learning to detect alternative splicing with high sensitivity and low sequencing depth.

The paper investigates the role of mitochondrial DNA in gene regulation across 48 tissues and 684 individuals, identifying eQTLs and associations with nuclear DNA genes.

This study shows that histone mark function, genomic distance, and cellular states collectively influence gene expression predictions using deep learning models, with no single mark consistently predicting expression across contexts.