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The paper characterizes genome organization and sex-biased gene expression in the vine mealybug, revealing female-skewed, spatially clustered expression patterns and lineage-specific secreted proteins.

The paper sequenced genomes of Poaceae sister species to identify metabolic innovations that predate grass evolution, revealing gene duplications linked to starch and lignin biosynthesis.

A web atlas counts evidence from 24 types for 188,634,118 variant-gene pairs across 50 human tissues; 1,530,420 pairs pass a high-confidence cutoff, 87% of them tissue-specific.

This study integrates prenatal exposures and genetics to predict DNA methylation at birth, finding that the exposome explains additional variation beyond genetic factors.

The paper investigates early Cd responses in developing oat caryopses and identifies non-canonical regulatory processes linked to low grain Cd accumulation.

This paper introduces a method using Oxford Nanopore long-read sequencing to measure chromosome-specific telomere lengths in human cells.

The paper presents a genome and transcriptome annotation of Cancer borealis, revealing neuronal gene structure and transcript diversity with high confidence.

The paper introduces miR-Space, a method for spatial miRNA profiling at single-cell resolution, revealing new miRNA distributions and cell-type associations in brain tissues.

VIPerturb-seq enables genome-wide CRISPR perturbation screens using probe-based detection, improving throughput and efficiency for single-cell analysis.

The paper shows that genome replication in yeast requires the cooperative activation of thousands of origins across the genome, driven by ORC binding and 3D chromosome folding.

The paper presents a near-complete, haplotype-resolved genome assembly of common buckwheat using trio-binning and Hi-C data, providing a valuable resource for genomic research and breeding.

The paper assembles and annotates a genome for a Chilean Tigriopus copepod population, suggesting it may represent a novel species based on divergence and morphology.

The paper presents a chromosome-level reference genome for the Saimaa ringed seal, identifies genomic features, and explores evolutionary relationships and adaptations.

The paper shows guide RNA binding causes reverse transcription bias in RT-qPCR for CRISPR systems and proposes a denaturation step to correct it.

Across UK Biobank, All of Us and FinnGen, the inferred mean direction (sign bias) of rare minor-allele effects varies and is largely explained by each cohort's trait skewness.

The paper identifies conserved influenza A epitope regions and evaluates ESM-2 sequence features for epitope prioritization, finding no significant improvement over alignment-based conservation.

EpiBinder predicts cell-type-specific TF binding by integrating DNA sequence and epigenetic data, improving prediction accuracy and providing interpretability.

This study infers nodavirus zoonotic transmission networks and explores genetic diversity using publicly available sequencing data.

The paper introduces RepTile, a framework to infer single-cell replication states from imaging data, revealing locus-specific dependencies of replication initiation on subnuclear position.

The paper maps context-dependent genetic regulation of cardiometabolic loci in human adipocytes using a multi-donor cell village system and single-nucleus multiome sequencing under various metabolic stress conditions.