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The paper identifies cryptic genetic diversity in Pacific herring, showing a biogeographic break linked to glacial cycles.

This study uses nanopore long-read sequencing to analyze genomic disruptions in Alzheimer's disease, finding increased retrotransposon activity and structural variants in aged brains.

The paper benchmarks human read removal methods in metagenomics, finding that high-sensitivity Bowtie2 with T2T-CHM13 reference improves removal while preserving microbial data.

The paper generates genome assemblies for ten brood parasitic bird species and their outgroups, enabling comparative genomic analyses of obligate brood parasitism evolution.

The paper improves click-code-seq for mapping DNA oxidation and depurination in human genomes, revealing strand bias in oxidized guanines and apurinic sites.

The paper analyzes over 800,000 human genomes to assess penetrance of clinically relevant variants, finding that 95% of pLoF variants in severe diseases have explanations for lack of disease manifestation.

This study identifies de-novo generation of ancestral horned variants in cattle through distinct recombination events at the POLLED locus, highlighting genetic complexity in polledness.

The paper constructs a comprehensive gut microbiome reference database from Chinese and non-Chinese populations, revealing population-specific microbial features linked to host physiology.

This study examines the evolution of gig immune genes in teleosts, focusing on Atlantic salmon, revealing distinct evolutionary trajectories and regulatory mechanisms.

The paper presents a single-nucleus RNA sequencing atlas of Aedes aegypti mosquitoes, identifying novel cell types and sexual dimorphism in gene expression across tissues.

The paper identifies somatic genomic alterations in neurons from CTE patients, finding patterns similar to Alzheimer's disease and suggesting mechanisms beyond repetitive head impacts.

The paper develops tools to analyze phased genomes of polar fishes, revealing haplotype diversity in antifreeze protein copy numbers while mitigating assembly errors.

This study identifies an expanded domoic acid biosynthesis gene cluster in Nitzschia navis-varingica through genome sequencing and biochemical validation, revealing its unique organization and evolutionary significance.

The paper identifies tumor-specific and subtype-specific alternative promoters in TNBC and develops a prognostic model based on these promoters, showing improved risk prediction.

The paper presents the first genome assembly of Potamopyrgus antipodarum, revealing a recent whole-genome duplication and its potential role in asexuality transitions.

The paper introduces MAGIC, a platform combining imaging and genomics to study de novo chromosome rearrangements, finding that dicentric chromosomes initiate CA events and TP53 deficiency increases CA rates.

This paper uses genotype imputation to analyze low coverage ancient goat genomes, revealing demographic patterns and genetic consequences of domestication.

The paper presents a pangenome and pantranscriptome of hexaploid oat, describing gene expression diversity and structural genome variation across 33 accessions and six tissues.

The paper introduces SegmentNT, a DNA foundation model for genome annotation, achieving state-of-the-art performance in identifying 14 genic and regulatory elements across species.

The paper identifies structural variants and coding polymorphisms in the human IGHC locus, revealing population-specific diversity and potential functional impacts.