Discover, rate, and discuss biology preprints.

The paper introduces LASSI, a method to measure nucleosome spacing in chromatin interactions, revealing fiber homotypy as a structural pattern influenced by genomic features and cohesin dynamics.

The paper analyzes single-cell multiome data from human HSPCs to show aging-related rewiring of gene regulatory networks, leading to stress hyperactivation, myeloid bias, and identity loss.

The paper reconstructs ancestral linkage groups in 340 dipteran genomes to study chromosome evolution, finding conserved groups in Nematoceran lineages and chromosomal fissions in Brachycera.

This paper identifies compartment- and cell-specific molecular programs in preclinical familial pulmonary fibrosis using multi-omic profiling and finds these signatures are partially represented in peripheral blood.

The paper compares sex-determining architectures in zebra and quagga mussels, finding divergent genetic systems and identifying potential contributors to rapid evolutionary changes in sex determination.

This study identifies molecular and immune mechanisms driving malignant transformation from inverted papilloma to sinonasal squamous cell carcinoma using multi-omics analyses.

The paper introduces CLASH, a method to quantify how genetic variation, methylation, and CTCF occupancy affect chromatin loop strength across individuals.

This study analyzes the genomic and epigenetic diversity of Salmonella enterica isolates from Kazakhstan, identifying distinct genetic clusters and epigenetic modifications linked to virulence and antibiotic resistance.

The paper assesses chromosomal radiosensitivity in G0-phase PBMCs from healthy donors, finding no significant age or sex effects and identifying genomic determinants of radiosensitivity.

The paper investigates chromosomal evolution in sedges and rushes, finding evidence of polycentromeres and their impact on genome rearrangement rates and segregation patterns.

This study identifies breeding pig trade as a key driver of swine influenza A virus dispersal across Europe using phylogeographic analysis of genomic sequences.

This study identifies shared and stress-specific adaptive pathways in rice under acidic soil metal toxicity using integrated meta-QTL and functional genomics analysis.

The paper develops a regression-based model to predict mRNA and protein abundance using codon weights derived from transcriptomic data, validated across multiple species.

The paper identifies composite MHC tagging at the MICA rs2596542 locus using carrier-set topology and NMF, revealing separable regulatory haplotypic backgrounds.

The paper uses a meta-analytic approach to identify sex-dependent splicing interactions in type 1 diabetes, finding higher prevalence in CD4 T cells than CD8 T cells.

This study investigates the role of transposons in Botrytis cinerea's adaptation to grapevine, identifying a new Starship transposon that confers arsenic resistance.

This paper introduces Shred-seq, a method to scan large-scale deletions in the human genome, revealing essential regions including noncoding sequences and establishing a lower bound for viability.

The paper characterizes human ectocentromeric sites as evolutionarily constrained and functionally heterogeneous elements along chromosome arms with context-dependent roles in chromatin state and transcription regulation.

This paper introduces a Bayesian multi-resolution spatial graphical regression framework to infer spatially varying gene networks from hierarchical spatial transcriptomics data, showing improved network recovery and identifying key regulatory hubs in kidney cancer.

The paper reanalyzes CLAP data to show PRC2 directly interacts with RNA in cells, correcting previous findings that missed this interaction due to a scaling step.