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This study shows Let-7b-5p promotes trophoblast migration and reduces sFlt-1 through TLR7 and TLR8, and its disruption mimics preeclampsia-like effects.

This study shows that TGF-β signaling in CD4 T cells regulates the balance between protective and regulatory immunity in visceral leishmaniasis by controlling T cell expansion, differentiation, and effector function.

Epitope-focused S2 stem-helix nanoparticle immunogens elicit protective broadly neutralizing antibodies against diverse betacoronaviruses in non-human primates, establishing a framework for pan-betacoronavirus vaccines.

This paper develops an autologous co-culture system to study human intestinal IEL-epithelial interactions, showing both non-destructive and cytotoxic responses under different conditions.

This study examines the relationship between sleep and anxiety in Chinese empty-nest older adults, finding that poor sleep quality and short sleep duration are independent risk factors, with physical exercise and social participation mediating these associations.

This paper describes the directed evolution of an antibody to enhance its binding affinity for MERS-CoV, resulting in cross-neutralization against multiple betacoronaviruses.

This study shows that Medihoney and a sugar-free Manuka honey extract inhibit Substance P-induced mast cell degranulation by suppressing MRGPRX2 activation, suggesting their potential as therapies for IC/BPS.

The paper develops RNA nanotherapeutics targeting TAMC cholesterol metabolism to enhance anti-tumor immunity in glioblastoma.

This paper shows that reducing BCL11B in CD8+ T cells enhances anti-tumor response by preventing exhaustion and boosting stemness and cytotoxicity.

The paper identifies T-cell co-signalling states linked to vulnerability and resilience to cerebral Aβ pathology in Alzheimer's disease.

Desialylation enhances bispecific T cell engager responses by relieving a sialoglycan-dependent restraint in human T cells.

This study identifies allergen-reactive Th2 cells in human airways using high-dimensional profiling and shows their systemic expansion following allergen challenge.

This study shows that personalized neoantigen vaccines combined with immune checkpoint therapy and CD8-targeted cytokines effectively control B-cell lymphoma by enhancing T-cell responses and preventing dysfunction.

This paper identifies IGF2BP3 as a critical amplifier of antiviral innate immunity, showing it enhances viral RNA sensing and IFN-I production, and reveals its role in autoimmune diseases.

This study uses CRISPR activation screening to identify surface ligands that regulate tumor sensitivity to NK cell killing, revealing new targets for improving NK cell-based immunotherapies.

This study shows that PIM1 in macrophages enhances CD36 expression and function, promoting foam cell formation and atherosclerosis, and that targeting this pathway could reduce plaque progression.

This study shows that neutrophils can be reprogrammed through transcriptional changes to enhance swarming and improve infection control in zebrafish.

This study shows that IL-10 deficiency in mice improves early control of Plasmodium yoelii infection without relying on IFN-γ, IL-12, or the humoral response.

This study identifies CK1 as a bimodal regulator of the cGAS-STING pathway, showing it both promotes DNA sensing and facilitates signaling termination, with therapeutic implications for cancer.