Discover, rate, and discuss biology preprints.

This study evaluates serum exosomal miR-23a and miR-23b as biomarkers for diagnosing coronary heart diseases, finding miR-23a is downregulated and predictive of stable angina and AMI.

This study evaluates a MinION-based sequencing method for detecting and characterizing RNA viruses using random priming and strand-switching, showing its effectiveness for known and unknown viruses.

This study shows that 15-PGDH inhibition improves hematopoietic and gastrointestinal tissue fitness in aged mice by enhancing regeneration and reducing inflammation.

This study shows extracellular histones stimulate collagen production in liver fibrosis via TLR4-MyD88 signaling, and NAHP reduces fibrosis by neutralizing histones.

The paper investigates the role of PKA in Carney complex testis tumors, showing that Prkar1a mutations in both stromal and Sertoli cells drive LCCSCTs via WNT4-dependent paracrine signaling.

This study evaluates vaccine-enhanced disease in ferrets and rhesus macaques after formalin-inactivated SARS-CoV-2 vaccination, finding mild transient lung pathology but no significant enhancement.

This study identifies gastrointestinal ulceration in calves as a common co-morbidity in those presenting to a referral hospital, with NSAID use significantly associated with ulcers.

The paper identifies subunits of the UDP-GlcNAc : PI α1-6 GlcNAc-transferase complex in Trypanosoma brucei using proteomics and immunoprecipitation.

The paper uses human proximal tubule cell models to study gene expression changes caused by ClC-5 loss-of-function mutations, revealing distinct molecular pathways affected by different mutations.

This study shows IL-13 induces OPG in liver tissue via a TGF-β-dependent pathway involving IL13 receptors and transcription factors STAT6 and AP1.

This study measures alveolar area and number in CD1 mice across aging to show increased area and decreased number with age.

The paper identifies microbial signatures in early liver fibrosis using statistical methods to address sample size and environmental differences.

This study shows that the GSH/GSSG ratio increases linearly with plasma preparation delay, suggesting it can indicate centrifugation delay.

This study shows that SARS-CoV-2 Spike protein activates macrophages and induces acute lung inflammation in mice.

The paper tests resistance of new cacao hybrids against Phytophthora megakarya using Leaf Disc and Whole Leaf Tests, identifying resistant and moderately resistant hybrids for breeding programs.

This study investigates how belt electrode-skeletal muscle electrical stimulation (B-SES) affects immobilization-induced muscle fibrosis by reducing macrophage accumulation and fibrotic markers in rats.

This study shows SARS-CoV-2 Spike protein damages endothelial cells by reducing ACE2 expression and impairing mitochondrial function, leading to vascular inflammation.

This study shows that loss of Tmem30a in podocytes causes albuminuria and glomerulosclerosis in mice, with reduced TMEM30A expression observed in human podocytopathies.

This study identifies and characterizes five garlic viruses using coat protein gene sequences, revealing complex mixtures and high diversity in Ethiopian garlic samples.

The paper investigates ACE2 expression and SARS-CoV-2 infection in human endothelial cells, finding low or absent ACE2 expression and no viral replication.