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The paper compares two automated DNA extraction methods for degraded skeletal remains, finding that QIAcube outperforms Prepfiler Express BTA in producing better DNA profiles.

This study shows that necrotizing enterocolitis (NEC) in preterm pigs leads to systemic immune suppression, increasing susceptibility to secondary infections.

This study evaluates phospho-β-catenin expression in primary and metastatic melanomas and finds no significant differences in staining location or intensity between the two, but notes high expression in dividing cells.

This study assesses the agreement between self-reported smoking and plasma cotinine levels in two cohorts of vulnerable individuals, finding high concordance and suggesting non-judgmental data collection improves reliability.

This study shows that FLCN gene ablation reduces fibrosis and inflammation in a diet-induced NASH model by enhancing autophagy and lysosomal biogenesis.

This study shows that Pseudomonas aeruginosa secretion causes acute emphysema in mice, which requires immune suppression and recapitulates human COPD features.

This paper shows that deleting Mcpip1 in liver-specific mice (Mcpip1AlbKO) causes a PBC-like disease, with features similar to human primary biliary cholangitis, including fibrosis, inflammation, and autoantibodies.

This study shows that in vitro cellular aging models can reflect multi-tissue epigenetic aging in vivo, using DNAmCULTURE as a measure that tracks aging across tissues and responds to interventions.

This paper evaluates an ensemble learning approach for automated knee cartilage segmentation using MR images from the Osteoarthritis Initiative, achieving high Dice coefficients and improved anatomical validity.

This study evaluates the effects of 15 bumped kinase inhibitors on zebrafish embryo development and mouse pregnancy, finding limited predictive value of zebrafish tests for pregnancy outcomes.

This study examines ACE2 and SARS-CoV-2 expression in normal and COVID-19 pancreas tissues, finding prominent ACE2 expression in ductal epithelium and microvasculature, with limited endocrine cell expression and no strong evidence of SARS-CoV-2 infection of endocrine cells.

This study shows SARS-CoV-2 infects human pluripotent stem cell-derived cardiomyocytes, causing electrical and mechanical dysfunction in cardiac cells.

This study investigates the role of resolvin D1 and D2 in reducing SARS-CoV-2-induced inflammation in cystic fibrosis macrophages.

This study evaluates rapamycin and platelet factor-4 on rat breast carcinoma, finding rapamycin effectively downregulates Flt-4 while platelet factor-4 shows limited anti-angiogenic effects.

This paper develops a deep learning system for gastric cancer detection using histopathological images, achieving high sensitivity and robust performance across different scanners.

This study shows that flagellin from Pseudomonas aeruginosa increases TMPRSS2 expression in airway epithelial cells, enhancing SARS-CoV-2 infectivity, particularly in CFTR-deficient cells.

This study shows that Stx2 induces cognitive deficits and inflammation in the hippocampus independently of ERK 1/2 signaling, while LPS requires ERK 1/2 for NF-kB activation.

The paper develops a deep learning method for analyzing kidney biopsy images to quantify podocyte loss, identifying morphometric signatures in ANCA-GN patients for risk stratification.

This study shows that hyperpolyploidization of hepatocytes in the centrilobular region initiates preneoplastic lesion formation, with AURKB upregulation and phosphorylation driving this process in HCC development.