Limited Defense of Liver Energy Status in Rats Susceptible to Diet-induced Obesity
This study shows that rats susceptible to diet-induced obesity have impaired liver energy status recovery during refeeding, linked to increased food intake.
363,000+ bioRxiv and medRxiv preprints, including those later published in peer-reviewed journals, across 26 biological disciplines.
This study shows that rats susceptible to diet-induced obesity have impaired liver energy status recovery during refeeding, linked to increased food intake.
X. Sun, Y. A. An, V. A. Paschoal…·D. Oh
This study shows that GPR84 promotes brown adipocyte function by regulating mitochondrial calcium and respiration, with implications for metabolic disease treatment.
A. K. Borowik, A. Davidyan, F. F. Peelor…·B. F. Miller
This study shows that skeletal muscle nuclei in mice can replicate in vivo through endoreplication, challenging the belief that they are post-mitotic.
A. M. R. Hayes, L. Tsan, A. E. Kao…·S. E. Kanoski
This study shows that early life consumption of low-calorie sweeteners affects energy balance and gene expression in adulthood, with sex- and sweetener-specific outcomes.
E. Reisman, J. Botella Ruiz, C. Huang…·D. J. Bishop
The paper examines fibre-specific mitochondrial protein abundance in human muscle before and after training, finding that most differences are linked to mitochondrial content rather than fibre-type-specific remodelling.
M. M. Al-Bataineh, C. L. Kinlough, A. L. Marciszyn…·E. C. Ray
This study investigates how MUC1 affects TRPV5 and TRPV6 trafficking and Ca2+ homeostasis, finding that MUC1 reduces endocytosis of these channels and influences blood Ca2+ levels in mice and humans.
R. M. Carey, B. M. Hariri, N. D. Adappa…·R. J. Lee
The paper shows that T1R3 in nasal cilia detects D-amino acids from Staphylococcus aureus to reduce airway surface liquid glucose and enhance innate immunity.
S. Gaspari, G. Labouebe, A. Picard…·B. Thorens
This study shows that Tmem117 in vasopressin neurons regulates glucagon secretion during hypoglycemia, with effects dependent on estrus cycle phase in female mice.
A. Casolo, S. Maeo, T. G. Balshaw…·A. Del Vecchio
This study establishes that motor unit conduction velocity can non-invasively estimate muscle fibre size in humans with moderate accuracy.
Y.-C. Chen, A. J. Taylor, J. M. Fulcher…·C. B. Verchere
This study shows that deleting CPE in beta cells disrupts proinsulin processing and alters beta cell identity, leading to impaired function and increased beta-cell area in mice.
C. P. Murphey, J. A. Shulgach, P. R. Amin…·B. J. Yates
This study measures physiological changes in felines before vomiting induced by copper sulfate, finding increased heart rate, decreased respiratory rate, and disrupted intestinal EMG activity as potential nausea markers.
A. A. Bernardin, S. Colombani, A. Rousselot…·A. C. Meli
This study develops an organ-on-a-chip model to study neuro-cardiac junctions using rat neurons and human cardiomyocytes, showing neuronal impact on cardiac function.
A. Green, B. L. Perras, H. Zhang…·J. Auwerx
This study shows that eliminating GCN5 in skeletal muscle does not improve mitochondrial content or metabolic markers under high-fat diet conditions, but may influence Pdk4 expression and fat metabolism.
M. E. Trautman, L. N. Braucher, C. Elliehausen…·D. W. Lamming
This study shows that high protein diets in mice can enhance muscle growth from resistance exercise without increasing fat mass, but do not improve glycemic control.
X. Wang, J. Cao, K. Han…·Z. Liu
This paper introduces a method using MRI and neural ODEs to model gastric motility and anatomy in rats, revealing functional regions and muscle activity patterns.
J.-L. Knop, N. Burkard, M. Danesh…·N. Schlegel
This study shows that soluble VE-cadherin fragments disrupt endothelial barrier function by interfering with VE-PTP/RhoA signaling in both in vitro and in vivo models.
P. M. Masschelin, P. Saha, S. A. Ochsner…·S. M. Hartig
This study shows that vitamin B2 deficiency impairs PPAR regulation of fasting glucose, and PPAR agonists can rescue this defect.
K. J. Prentice, A. Lee, P. Cedillo…·G. S. Hotamisligil
This study shows that ATGL is not required for lipolysis-stimulated FABP4 secretion from adipocytes, which can occur via sympathetic signaling.
B. M. Culbert, S. E. Border, R. J. Fialkowski…·P. D. Dijkstra
The paper examines how social rank in cichlid fish affects the relationship between hormones and oxidative stress markers across different tissues.