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This study uses computational modeling to show that AT1R-mediated uptake, not increased local Ang II production, drives intrarenal Ang II accumulation during Ang II infusion, contributing to hypertension.

This study shows that inhibiting SLC4A4, a sodium-dependent bicarbonate cotransporter, in airway epithelial cells causes a CF-like phenotype with mucus accumulation and reduced mucociliary clearance.

This study compares protein turnover rates in mouse tissues using two labeling methods, showing they yield similar results for long-lived proteins but require adjustments for short-lived proteins.

The paper uses computational models to identify physiological factors that increase susceptibility to triple whammy acute kidney injury.

This study shows that food restriction increases sensitivity to alpha1-adrenergic mediated contraction in mesenteric arteries by reducing eNOS-NO pathway function and increasing ROS through NOX2/4 activation in male rats.

The paper shows TRPV4 activates TMEM16F in trophoblasts, promoting cell fusion, and identifies this as a mechanism for syncytialization and disease-related fusion.

This paper introduces a 3D 7T 31P-MRSI sequence for cardiac imaging that significantly reduces scan time while maintaining high SNR and spatial resolution.

This study identifies specific lipid signatures in adipose-derived extracellular vesicles (AdEV) from lean and obese mice, revealing their role in obesity-associated metabolic dysfunctions.

This study shows boron alleviates aluminum toxicity in Arabidopsis roots by restoring PIN2 endocytosis and auxin transport, reversing auxin depletion in the elongation zone.

This study investigates autophagy's role in heat-stress tolerance in Drosophila melanogaster, finding that heat stress induces autophagy and rapamycin enhances heat tolerance through autophagy activation.

This study uses calcium imaging to compare calcium oscillations, waves, and network dynamics in human islets from donors with and without type 2 diabetes, finding altered glucose responses and network structure in diabetic islets.

The paper measures geographic variation in cold tolerance of an invasive forest insect's larvae across its invasion range in the Eastern US and finds regional climate influences recovery from cold exposure.

This study shows that intestinal SEC16B is essential for dietary lipid absorption, with its loss protecting mice from obesity.

This paper identifies CaMK1D as a key mediator of ghrelin-induced food intake in AgRP neurons, showing its role in promoting orexigenic neuropeptide expression and obesity resistance.

This study evaluates the effect of exogenous Galectin-1 on pregnancy rates in beef cattle during artificial insemination, finding an 8.68% increase in pregnancy probability.

This study identifies a novel kidney regeneration mechanism triggered by physiological stress, involving macula densa cells controlling progenitor cells through secreted factors.

This study shows that a specific static magnetic field reduces oxidative stress and liver damage caused by alcohol consumption in mice.

This study shows that C. elegans vertically transmits gut bacteria to offspring, which colonize tissues during development and influence immunity.

The paper identifies the macula densa cells in the kidney as neuron-like structures with functions similar to interoceptive neurons, regulating organ functions through local neural networks.

This study shows EFEMP1 is crucial for elastic fiber formation and mechanical properties of the extrahepatic bile duct, with reduced EFEMP1 leading to increased compliance and potential role in biliary atresia.