Discover, rate, and discuss biology preprints.

The paper develops the Recovery-Burden Index (RBI), a glucose-only metric from OGTT profiles that accurately predicts DI and detects beta-cell dysfunction.

This study identifies RUNX1 as a key transcriptional regulator of fibrogenic and inflammatory signaling in cholangiocytes, showing its inhibition reduces biliary fibrosis and inflammation in models of cholangiopathy.

This study investigates the role of ZO-1 in sinoatrial node automaticity and finds that its loss reduces pacemaker current and impairs atrial conduction, leading to bradyarrhythmia.

The paper shows liver-targeted copper supplementation reduces steatosis by enhancing lipolysis and fatty acid oxidation through copper-dependent metabolic pathways.

This study shows that exposure to urban green spaces reduces subjective stress and physiological arousal compared to gray spaces during naturalistic walking.

This study compares the structural and functional properties of porcine left atrial and ventricular myosin filaments, revealing distinct calcium-dependent regulatory mechanisms between the two chambers.

This paper develops a neonatal rat sepsis model and scoring system to monitor disease severity and time course in a clinically relevant polymicrobial sepsis context.

The paper shows that acetate from gut microbiota maintains acetyl-CoA levels in colonic epithelial cells, preventing age-independent senescence and inflammation.

This study shows that tardigrades resist extreme hypergravity through increased intracellular viscosity and NOX-dependent ROS production.

This study shows workload-induced β-cell overstimulation leads to failure in T2D, identifying a compensating transcriptional state and the role of Lsd1 in restraining state transitions.

This study investigates the therapeutic effects of synthetic Relaxin-2 in HFpEF, showing it reverses diastolic dysfunction and reduces arrhythmia vulnerability in ZSF1 rats.

This study shows that acute buprenorphine exposure reduces ventilation and metabolic rates in neonatal rats, with pre-treatment with naloxone mitigating these effects.

This study examines how aerobic exercise affects small RNA expression in skeletal muscle and plasma, linking changes to improved insulin sensitivity.

This study quantifies how ankle immobility affects sprint cycling performance, showing reduced power output with AFOs but compensatory increases in hip joint power.

This study shows estrogen and nitric oxide signaling reduce oxLDL uptake and oxidative stress in endothelial cells, modulate mitochondrial dynamics, and decrease inflammation, protecting against early atherosclerosis.

This study shows that octopaminergic signaling in honey bees adapts to elevation by increasing brain octopamine levels and receptor expression in flight muscles, enhancing thermogenic performance under cold stress.

This study shows that fatty acids from adipocyte lipolysis stimulate insulin secretion via FFAR4 and FFAR1 receptors, highlighting adipose-islet crosstalk in metabolic regulation.

This study identifies length-dependent hypercontractility as the initial phenotype of MYBPC3-haploinsufficiency in iPSC-derived cardiac tissues, decoupled from early transcriptional and metabolic changes.

This study shows that pulmonary fibrosis enhances CGRP-induced hyperpolarization and vasodilation in male mice through PKA-dependent KATP channel activation, with no effect in females.