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This study shows ZIP14 facilitates manganese efflux from the brain by relocalizing to the basolateral membrane in BBB endothelial cells, and its deletion causes Mn accumulation.

This study investigates the role of BAT ADH5 in aging, showing that its loss accelerates BAT senescence and metabolic decline, while HSF1 activation mitigates these effects.

This study shows that nutrient excess remodels pancreatic islet innervation through Schwann cells, impairing glycemic control, and demonstrates that neuromodulation can improve outcomes.

This study investigates whether oral contraceptive use affects grip strength and neuromuscular activation in females during wrist/hand immobilization and rehabilitation, finding no significant differences between OC users, non-users, and males.

The paper introduces the corrected oxygenation gradient (COG) as a new metric that integrates gas exchange, oxygen extraction, and ventilatory adequacy to improve diagnostic precision in respiratory and circulatory conditions.

This study identifies a proteomic signature in humans following acute cold exposure that correlates with cardioprotective and anti-aging effects.

The paper investigates how loss of pulsatile flow affects pulmonary vascular structure in SV-CHD patients and identifies PDGFB as a key mediator of vascular remodeling.

This study identifies CtBP as a redox state sensor that controls enteroendocrine cell fate in Drosophila by integrating metabolic signals with transcriptional regulation.

This study identifies a cytokine-mediated signaling pathway in Drosophila that coordinates systemic hypoxia tolerance, revealing sex-specific requirements and a regulatory role for HIF-1/sima.

This study shows that high-fat diet reduces Usp25m in mice, impairing TUG cleavage and glucose uptake during fasting, leading to insulin resistance in skeletal muscle.

This study investigates the biological mechanisms of orthorexia by examining gastric and facial responses to different types of foods in a non-clinical sample.

This paper measures free-swimming jellyfish metabolic rates using non-invasive volumetric laser scanning and finds they consume 2.5 times more energy than constrained animals.

This study examines the effects of combined respiratory muscle training on sleep and cardiovascular metrics in a non-clinical population, finding improved heart rate variability but no changes in sleep quality.

This study shows that dopamine regulates photoreceptor photoresponse properties in lamprey differently than in jawed vertebrates.

This study shows that remote ischaemic preconditioning protects the heart by releasing GLP-1, which relaxes cardiac pericytes and reduces no-reflow.

This study examines the effects of theta-burst transcranial focused ultrasound on cerebral blood flow, functional connectivity, and metabolite levels in the primary motor cortex using multimodal neuroimaging.

This study shows FoxO1 in the medial preoptic area (MPOA) influences metabolic adaptation to diet and temperature, with effects specific to female mice.

This study shows that TMS-evoked potentials (TEPs) can have distinct spatiotemporal patterns lasting up to 300 ms when targeting specific cortical areas, challenging the view that later components are due to sensory inputs.

This paper shows indole, a gut microbial metabolite, improves glucose control by boosting GLP-1 secretion and L-cell differentiation in mice, suggesting it could be used as a therapeutic for type 2 diabetes.

This study shows that high fat diet induces DNA methylation at the Esr1 promoter in adipose tissue, reducing Esr1 expression and increasing inflammation, which can be reversed by targeting methylation.