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This study shows formate reduces ischemic injury in female ADH5-/- hearts but not in intact female or ovariectomized WT hearts, suggesting estrogen-dependent formate utilization in OCM is critical for cardioprotection.

This study shows that a low protein diet enhances metabolic health and weight loss in mice after sleeve gastrectomy, challenging current high-protein dietary recommendations.

This study develops an in vivo rheological method to assess skeletal muscle stiffness and elasticity in dystrophin-deficient mice, finding increased stiffness and impaired recovery in mdx mice.

The paper evaluates the DrugAge database, finding poor reporting quality and inconsistent effect sizes in anti-aging preclinical studies across species.

This study shows that bleomycin-exposed ferrets develop sustained pulmonary fibrosis, restrictive lung physiology, and airway remodeling similar to human IPF.

This study shows estrogen signaling in Reprimo lineage cells affects thermoregulation in female mice by altering brown adipose tissue thermogenesis, but not in males.

This study compares anthropometric traits and physical capacities of Indonesian junior badminton players by age and sex, finding age-related differences in BMI, strength, and sprint performance, but similar aerobic capacity across groups.

This study develops a novel measure of sympathetic vascular control, sympathetic vasomotion, which increases before hemodynamic changes and could serve as an early marker of hemorrhage.

This study examines how embryonic hypoxia and hypothermia affect cardiovascular structure and function in chickens, revealing sex-specific differences in mitochondrial morphology and ventricular hypertrophy.

The paper shows reduced ZMPSTE24 leads to prelamin accumulation and steatosis in MASLD patients, linking it to p53 activation and metabolic dysfunction.

This study shows that absence of complement factor D increases pressure-pain hyperalgesia in mice after medial meniscus injury despite cartilage protection.

This study shows that soluble fiber inulin reduces liver fat and metabolic issues in mice on a Western diet, while insoluble fiber cellulose does not, suggesting inulin's benefits come from its effect on gut microbiota.

This study investigates how emotionally charged immersive VR affects spinal reflex excitability in healthy adults, finding differential effects on dominant and non-dominant limbs.

This study shows HIF-1α and HIF-2α differentially regulate lung alveolar macrophage function, with HIF-2α playing a central role in impaired maturation and surfactant clearance.

This study shows that Ulk1(S555) phosphorylation regulates metabolic flexibility by prioritizing amino acid metabolism during nutrient stress.

The paper shows Gβγ interacts with GIRK2 and GIRK1/2 channels with affinities in the microM range, with GIRK1/2 having higher apparent affinity due to a unique Gβγ docking site.

This paper investigates how piperine affects resting thick filament activation and dynamic contractility in fast and slow rat skeletal muscles, finding fiber-type-dependent enhancements in contractile function.

This study evaluates a water-soluble Passiflora incarnata formulation's effect on sperm motility, finding it reduces motility without affecting viability, suggesting potential as a non-hormonal contraceptive.

This study shows that loss of CEACAM2 in mice impairs renal insulin clearance, leading to hyperinsulinemia, insulin resistance, and kidney dysfunction.

This study examines how KCNC1 gene polymorphisms affect blood lipid levels and response to high-intensity interval training in young Han Chinese individuals, finding sex-specific associations.