Discover, rate, and discuss biology preprints.

This study investigates the role of PKD in adipose tissue, revealing sex-dependent effects on metabolism through phosphoproteomics and a mouse model.

This study characterizes the miRNA composition of skeletal muscle-derived extracellular vesicles and identifies their involvement in key biological pathways and potential therapeutic roles.

This study examines how sinusoidal speed changes with different amplitudes and periods affect gait variability and step followability in healthy young adults.

This study investigates neural adaptations in muscle strength and force steadiness in untrained limbs after unilateral training, finding reduced synaptic input variability and increased neural drive in trained and contralateral limbs.

This study shows that developmental cold exposure in Japanese quail increases mitochondrial susceptibility to heat stress, with effects reversible after acclimation to moderate temperatures.

This study shows that the AML chemotherapy regimen induces cachexia in mice, characterized by body and lean mass loss, and identifies haptoglobin as a potential biomarker for chemotherapy-induced cachexia.

The paper introduces MACanalyzeR, a scRNA-seq tool, to identify PPARγ-high lipid-associated macrophages in BAT that support thermogenic expansion.

The paper uses multispectral optoacoustic tomography and a novel near-infrared dye to measure glomerular filtration rate in healthy mice and after ischaemic reperfusion injury.

The paper shows that clustering of voltage-gated sodium channels affects their biophysics, leading to different pharmacological responses and potential therapeutic implications.

This study shows that APOE4 increases lipid droplet accumulation and alters their composition in microglia, resembling a pro-inflammatory state, and overlaps with AD-associated proteomes.

This study investigates how APOE genotype affects sleep architecture, finding that APOE4 homozygotes have higher arousal thresholds and reduced sleep spindle activity.

This study examines how morning resistance exercise affects afternoon physical and cognitive performance in male rugby players, finding improvements in physical performance but not cognitive tasks.

A dietary intervention after stopping incretin analog therapy restores adipose tissue function and prevents weight regain in diet-induced obese mice.

This study shows that FGF21 deletion worsens hepatic dysfunction in rats fed a MASH diet and alcohol, but does not affect body weight or liver transcriptome in the diet model.

This study shows antioxidant supplementation reduces proteome changes in type 2 muscle fibers during sprint interval training, but not performance improvements.

This study maps the proteomic changes in plasma, saliva, and urine after acute exercise, identifying over 3,000 regulated proteins and their associations with disease and drug targets.

This study shows that combining trametinib and rapamycin extends mouse lifespan more than either drug alone and improves health markers in older age.

The paper identifies a common fibro-adipogenic progenitor population in both white and brown adipose tissue using single-cell RNA sequencing and validates its physiological relevance through comparison with in vivo data.

This study shows that renal sympathetic vasomotion decreases after catheter-based radiofrequency renal denervation, indicating its potential as a feedback tool for the procedure.