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Long-range allosteric restraint by the Spiral-Pincer scaffold gates oxidative activation of the ATM kinase

The paper investigates how the Spiral-Pincer scaffold regulates ATM kinase activation by oxidative stress, showing it restricts access to an oxidation-competent conformation.

A comparative analysis of BrdU and EdU genotoxicity shows that trypanosomatids exhibit unique responses to the presence of these thymidine analogs in their DNA

This study compares the genotoxic effects of BrdU and EdU in trypanosomatids, finding EdU more genotoxic and revealing species-specific responses to DNA damage.

FastaGuard: FASTA preflight QC for modern bioinformatics pipelines

FastaGuard is a FASTA preflight QC tool that detects structural issues in assemblies and stops pipelines before expensive analysis, with high accuracy in identifying faults.

irAEGIS: Pathway-guided interpretable prediction of immune-related adverse events

irAEGIS predicts immune-related adverse events from pre-treatment scRNA-seq data using a pathway-guided interpretable model, outperforming existing methods and identifying biologically relevant immune programs.

Parkinson Disease vs Aging Features Impairments in Formation and Release of a Power Grip in Real and Pantomimed String-Pulling

This study compares movement impairments in Parkinson's disease, aging, and young adults during real and pantomimed string-pulling tasks, identifying differences in speed, workspace, and hand shaping.

The mouse Cdh23ahl allele drives early cochlear dysfunction and phenotypic heterogeneity before progressive hearing loss

This study shows the Cdh23ahl allele causes early cochlear dysfunction and phenotypic variability in mice before progressive hearing loss, with altered mechanoelectrical transduction and transcriptional changes.

CNVision: a computational framework for functional interpretation of intragenic copy number variants

CNVision is a computational framework that automates the interpretation of intragenic copy number variants by standardizing input parsing, transcript mapping, and reading-frame classification.

Multi-scale place fields provide a predictive basis for hierarchical control

This paper introduces a predictive map model that explains multi-scale place field activity in hippocampal neurons and validates its predictions with experimental data.

Establishing de novo microbial biosynthesis of anisole

This paper develops a microbial pathway to produce anisole from glucose using engineered Pseudomonas putida, achieving 0.57 mM anisole production.

Circadian feeding rhythm loss drives sex-specific β-cell dysfunction in diet-induced obesity

This study shows that diet-induced obesity disrupts circadian β-cell function more in male mice than females, with time-restricted feeding partially restoring these effects.

Embodied Dynamic Causal Modelling: Brain and Cardiac Effective Connectivity

This paper introduces Embodied Dynamic Causal Modelling to estimate effective connectivity across the brain-heart axis using multimodal data from an auditory Go/No-Go task.

Ark-ADMET: endpoint-specific selection of molecular representations and hyperparameters for gradient-boosted ADMET models under the Therapeutics Data Commons benchmark protocol

Ark-ADMET selects endpoint-specific molecular representations and hyperparameters for gradient-boosted ADMET models, achieving competitive performance without new architectures or shared representations.

Cigarette smoke extract and palmitic acid exposed patient-derived iPS- RPE cells as a model for AMD

This study examines how cigarette smoke extract and palmitic acid affect patient-derived iPSC-RPE cells, showing increased susceptibility in AMD-derived cells with altered stress responses and function.

Chromosomally-Encoded Hok/Sok Toxin/Antitoxin SystemsInhibit Phage Infection

This study investigates the role of chromosomally-encoded Hok/Sok toxin/antitoxin systems in inhibiting phage infection in E. coli, finding that Hok proteins significantly reduce infection by BASEL phages.

GxE and changes to the genetic architecture of flowering time in an overwintering environment

This study examines how genetic architecture of flowering time in Arabidopsis thaliana changes between overwintering environments and growth chambers, finding extensive gene-by-environment interaction and environment-specific genetic effects.

Proteolytic feedback of quorum sensing promotes infection by Pseudomonas aeruginosa

This study shows that proteolytic feedback regulates quorum sensing in Pseudomonas aeruginosa by controlling RhlR stability, affecting virulence and biofilm formation.

Anorectal care products cause variable inflammation and adverse barrier effects in a mucosal epithelial model

This study evaluates the effects of anorectal care products on mucosal epithelial models, finding that hyperosmolar and surfactant-containing products cause inflammation and barrier disruption, while isotonic formulations are less harmful.

Application of organic fertilisation such as poultry manure enhanced carbohydrate, fat and vitamin C contents of Huckleberry (Solanum scabrum) more than mineral fertilisation in Buea-Cameroon

This study compares the effects of organic and inorganic fertilizers on huckleberry growth and nutritional content, finding that poultry manure enhances micronutrients more than urea, which boosts yield.

Unravelling the mechanisms of clozapine-induced neutropenia in treatment-resistant schizophrenia using cellular genomics

This study investigates clozapine-induced neutropenia in treatment-resistant schizophrenia using single nucleus RNA sequencing to identify cell type-specific transcriptional changes and cell-cell communication patterns.

Short-term changes in a chicken comb vascular model mimicking port-wine stain after synchronous ultrasound parallel beam treatment: an exploratory study

This study examines the short-term effects of SUPERB ultrasound treatment on a chicken comb model, finding reduced vascular caliber and VEGF-A expression but no consistent collagen changes.