T. Hara

Defining ancestry, heritability and plasticity of cellular phenotypes in somatic evolution

The paper introduces PATH, a framework to quantify heritability and plasticity of cellular phenotypes in somatic evolution using single-cell data from mouse and human samples.

Lysyl oxidase regulates epithelial differentiation and barrier integrity in eosinophilic esophagitis

This study shows LOX promotes epithelial differentiation and barrier integrity in EoE by activating the BMP pathway through increased BMP2 and reduced follistatin.

A microglia-CD4+ T cell partnership generates protective anti-tumor immunity to glioblastoma

This study identifies a microglia-CD4+ T cell interaction that enhances anti-glioblastoma immunity through IFN-gamma-mediated tumor surveillance and phagocytosis.

Virological characteristics of SARS-CoV-2 BA.2 variant

This study compares the virological characteristics of SARS-CoV-2 BA.2 and BA.1 variants, finding BA.2 has higher transmissibility, different antigenicity, greater replicative capacity, and higher pathogenicity in hamsters.

The transcriptional hallmarks of intra-tumor heterogeneity across a thousand tumors

This study integrates single-cell RNA-seq data from 1,163 tumors across 24 types to identify 41 consensus transcriptional programs and 11 hallmarks of intra-tumor heterogeneity.

Elevated METTL9 is associated with peritoneal dissemination in human scirrhous gastric cancers

This study identifies METTL9 as a key factor in peritoneal dissemination of scirrhous gastric cancers by showing its role in mitochondrial function and metastatic activity.

An autonomous tail-beating cycle period expressed by a region-specific swimming pattern generator in the Ciona larva

The paper identifies a region-specific swimming pattern generator in Ciona larva mid-piece fragments that autonomously produce periodic tail beating without external stimuli.