Author

K. A. Whelan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 4 Organism:mouse· 4 Assay:scRNA-seq· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

K. E. Hamilton· 4 shared A. Klochkova· 3 shared L. R. Parham· 3 shared A. B. Muir· 2 shared A. D. Fuller· 2 shared A. Klein-Szanto· 2 shared A. L. Karami· 2 shared A. Mu· 2 shared

Activity by Year

2022-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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4 shared papersCell Biology

K. E. Hamilton

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Lysyl oxidase regulates epithelial differentiation and barrier integrity in eosinophilic esophagitis

M. Sasaki, T. Hara, J. X. Wang, Y. Zhou, K. V. Kennedy, N. N. Umeweni, M. A. Alston, Z. C. Spergel, R. Nakagawa, E. A. McMillan, K. A. Whelan, T. A. Karakasheva, K. E. Hamilton, M. A. Ruffner, A. B. Muir

This study shows LOX promotes epithelial differentiation and barrier integrity in EoE by activating the BMP pathway through increased BMP2 and reduced follistatin.

Cellular and Molecular Gastroenterology and Hepatology · Jan 1, 2024Peer-reviewedCell Biology

Autophagy contributes to homeostasis in esophageal epithelium where high autophagic vesicle content marks basal cells with limited proliferation and enhanced self-renewal potential

A. Klochkova, A. L. Karami, A. D. Fuller, L. R. Parham, S. R. Panchani, S. Natarajan, J. L. Jackson, A. Mu, Y. Tan, K. Q. Cai, A. Klein-Szanto, A. B. Muir, M.-P. Tetreault, K. E. Hamilton, K. A. Whelan

The paper investigates autophagy's role in esophageal homeostasis, finding that high autophagic vesicle content in basal cells correlates with limited proliferation and enhanced self-renewal.

bioRxiv · Sep 20, 2023 · PreprintPhysiology

Eosinophilic esophagitis-associated epithelial remodeling may limit esophageal carcinogenesis

A. D. Fuller, A. L. Karami, M. F. Kabir, A. Klochkova, J. L. Jackson, A. Mu, Y. Tan, A. Klein-Szanto, K. A. Whelan

This study compares single-cell RNA-sequencing data from murine models of eosinophilic esophagitis (EoE) and esophageal squamous cell carcinoma (ESCC) to show that EoE inflammation limits esophageal carcinogenesis through distinct epithelial remodeling.

bioRxiv · Nov 28, 2022 · PreprintCell Biology

Autophagic state prospectively identifies facultative stem cells in the intestinal epithelium

N. M. Johnson, L. R. Parham, J. Na, K. E. Monaghan, H. M. Kolev, A. Klochkova, M. S. Kim, C. H. Danan, Z. Cramer, L. A. Simon, K. E. Naughton, S. Adams-Tzivelekidis, Y. Tian, P. A. Williams, N. A. Leu, , K. E. Hamilton

The paper identifies autophagic state as a marker for facultative stem cells in the intestinal epithelium, independent of lineage or cell age.

bioRxiv · Apr 8, 2022Cell Biology

IGF2BP1/IMP1 deletion enhances a facultative stem cell state via regulation of MAP1LC3B

L. R. Parham, P. A. Williams, P. Chatterji, K. Acheampong, C. H. Danan, K. Katada, X. Ma, L. A. Simon, K. E. Naughton, R. Mizuno, T. Karakasheva, E. A. McMillan, K. A. Whelan, D. C. Brady, S. M. Shaffer, K. E. Hamilton

The paper shows that deleting IGF2BP1/IMP1 enhances autophagy and tissue regeneration by regulating MAP1LC3B through phosphorylation and cell stress.

bioRxiv · Feb 28, 2022 · PreprintCell Biology