Author

O. S. Rosenberg

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Microbiology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Assay:cryo-EM· 2 Approach:deep learning· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Approach:statistical model· 2 Organism:bacteria (other)· 1

Frequent Co-Authors

A. Glasgow· 2 shared I. Lui· 2 shared J. A. Wells· 2 shared K. K. Leung· 2 shared Y. Zhang· 2 shared A. D. Grossman· 1 shared A. F. Britol· 1 shared A. M. Smith· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiochemistry

A. Glasgow

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Structure and dynamics of the essential endogenous mycobacterial polyketide synthasePks13

S. K. Kim, M. S. Dickinson, J. S. Finer-Moore, Z. Guan, R. M. Kaake, I. Echeverria, J. Chen, E. H. Pulido, A. Sali, N. J. Krogan, O. S. Rosenberg, R. M. Stroud

This paper determines the structure and dynamics of the mycobacterial polyketide synthase Pks13 using cryoEM and complementary techniques, revealing intermediate states and substrate binding.

bioRxiv · Jan 27, 2023Biochemistry

Computational pipeline provides mechanistic understanding of Omicron variant of concern neutralizing engineered ACE2 receptor traps

S. G. Remesh, G. E. Merz, A. F. Britol, U. S. Chio, A. N. Rizo, T. H. Pospiech, I. Lui, M. T. Laurie, J. Glasgow, C. Q. Le, Y. Zhang, D. Diwanji, E. Hernandez, J. Lopez, K. I. Pawar, , K. A. Verba

The paper develops a computational pipeline combining Rosetta and cryo-EM to analyze ACE2 receptor traps' binding to SARS-CoV-2 variants, showing high affinity and neutralization capabilities against Omicron and Delta.

bioRxiv · Aug 9, 2022Biochemistry

The ESX-1 secretion system senses bacterial contact and prepares mycobacteria for environmental adaptation

N. Herrera, P. D. Odermatt, M. Voorhies, R. Nakagawa, A. Sil, F. Chang, O. S. Rosenberg

The paper shows the ESX-1 system in mycobacteria senses bacterial contact and environmental nitrogen levels, regulating secretion and adaptation.

bioRxiv · Oct 17, 2021 · PreprintMicrobiology

Engineered ACE2 receptor traps potently neutralize SARS-CoV-2

A. Glasgow, J. E. Glasgow, D. Limonta, P. Solomon, I. Lui, Y. Zhang, M. A. Nix, N. J. Rettko, S. A. Lim, S. Zha, R. Yamin, K. Kao, O. S. Rosenberg, J. V. Ravetch, A. P. Wiita, , J. A. Wells

This paper describes engineered ACE2 receptor traps that potently neutralize SARS-CoV-2 by blocking viral entry through enhanced binding affinity.

bioRxiv · Jul 31, 2020Bioengineering

Mobile-CRISPRi: Enabling Genetic Analysis of Diverse Bacteria

J. M. Peters, B.-M. Koo, R. Patino, G. E. Heussler, C. C. Hearne, Y. Inclan, J. S. Hawkins, C. H. S. Lu, M. M. Harden, H. Osadnik, J. E. Peters, J. N. Engel, R. J. Dutton, A. D. Grossman, C. A. Gross, O. S. Rosenberg

The paper introduces Mobile-CRISPRi, a CRISPRi system for non-model bacteria, demonstrating its use in analyzing gene function and antibiotic resistance in human pathogens.

bioRxiv · May 5, 2018Microbiology