Author

A. E. M. Beedle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 4 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:metabolism & bioenergetics· 2 Research Focus:protein folding & dynamics· 2 Research Focus:development & morphogenesis· 1 Organism:human· 1 Assay:metabolomics· 1

Frequent Co-Authors

I. Andreu· 4 shared P. Roca-Cusachs· 4 shared X. Trepat· 4 shared A. Elosegui-Artola· 2 shared N. Chahare· 2 shared Z. Kechagia· 2 shared A. Albajar-Sigales· 1 shared A. Jaganathan· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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4 shared papersBiophysics

I. Andreu

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Fibrillar adhesion dynamics govern the timescales of nuclear mechano-response via the vimentin cytoskeleton

A. E. M. Beedle, A. Jaganathan, A. Albajar-Sigales, F. M. Yavitt, K. Bera, I. Andreu, I. Granero-Moya, D. Zalvidea, Z. M. Kechagia, G. Wiche, X. Trepat, J. Ivaska, K. S. Anseth, V. Shenoy, P. Roca-Cusachs

The paper shows that fibrillar adhesions control nuclear mechanical response timescales through vimentin cytoskeleton anchoring via plectin 1f.

bioRxiv · Nov 8, 2023Biophysics

The laminin-keratin link shields the nucleus from mechanical deformation and signalling

Z. Kechagia, P. Saez, M. Gomez-Gonzalez, M. Zamarbide, I. Andreu, T. Koorman, A. E. M. Beedle, P. W. B. Derksen, X. Trepat, M. Arroyo, P. Roca-Cusachs

This study shows laminin-111 shields the nucleus from mechanical deformation by linking integrin {beta}4 to keratin, affecting YAP localization and chromatin methylation in breast epithelial cells.

bioRxiv · Mar 1, 2022Cell Biology

Mechanosensitivity of nucleocytoplasmic transport

I. Andreu, I. Granero, N. Chahare, K. Clein, M. Molina Jordan, A. E. M. Beedle, A. Elosegui-Artola, X. Trepat, B. Raveh, P. Roca-Cusachs

Force application to the nucleus leads to nuclear accumulation of proteins by differentially affecting passive versus facilitated nucleocytoplasmic transport.

bioRxiv · Jul 23, 2021 · PreprintBiophysics

The force loading rate drives cell mechanosensing through both reinforcement and fluidization

I. Andreu, B. Falcones, S. Hurst, N. Chahare, X. Quiroga, A.-L. Le Roux, Z. Kechagia, A. E. M. Beedle, A. Elosegui-Artola, X. Trepat, R. Farre, T. Betz, I. Almendros, P. Roca-Cusachs

This study shows that the rate of force application drives cell mechanosensing through reinforcement and fluidization mechanisms.

bioRxiv · Mar 8, 2021Biophysics

Molecular fluctuations as a ruler of force-induced protein conformations

A. Stannard, M. Mora, A. E. M. Beedle, M. Castro-Lopez, S. Board, S. Garcia-Manyes

This study uses single molecule magnetic tweezers to analyze variance in protein end-to-end fluctuations under force, showing that compliance changes scale with contour length and align with the FJC model.

bioRxiv · Dec 18, 2020Biophysics