Author

A. M. Westermark

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:bulk RNA-seq· 2 Organism:human· 2 Research Focus:metabolism & bioenergetics· 2 Assay:metabolomics· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

E. C. Lien· 4 shared M. Vander Heiden· 4 shared Z. Li· 3 shared A. N. Lau· 2 shared K. M. Sapp· 2 shared L. V. Danai· 2 shared A. M. Darnell· 1 shared A. M. Hosios· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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4 shared papersCancer Biology

E. C. Lien

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Effects of aging on glucose and lipid metabolism in mice

E. C. Lien, N. Vu, A. M. Westermark, L. V. Danai, A. N. Lau, Y. Gultekin, M. A. Kukurugya, B. D. Bennett, M. Vander Heiden

This study examines how aging affects glucose and lipid metabolism in mice, finding that NAD+ levels remain stable but lipid metabolism increases in aged tissues.

bioRxiv · Dec 17, 2023Physiology

Cancer cells depend on environmental lipids for proliferation when electron acceptors are limited

Z. Li, B. W. Ji, P. D. Dixit, E. C. Lien, K. Tchourine, A. M. Hosios, K. L. Abbott, A. M. Westermark, E. F. Gorodetsky, L. B. Sullivan, M. Vander Heiden, D. Vitkup

This study shows that cancer cells rely on environmental lipids for proliferation under conditions of limited electron acceptors, such as hypoxia or mitochondrial inhibition.

bioRxiv · Jun 8, 2020Cancer Biology

Dissecting cell type-specific metabolism in pancreatic ductal adenocarcinoma

A. N. Lau, Z. Li, L. V. Danai, A. M. Westermark, A. M. Darnell, R. Ferreira, V. Gocheva, S. Sivanand, E. C. Lien, K. M. Sapp, J. R. Mayers, G. Biffi, C. R. Chin, S. M. Davidson, D. A. Tuveson, , M. Vander Heiden

The paper uses isotope tracing to compare metabolism between cancer cells and fibroblasts in pancreatic tumors, identifying key metabolic dependencies in cancer cells.

bioRxiv · Mar 9, 2020Cancer Biology

Caloric restriction alters lipid metabolism to contribute to tumor growth inhibition

E. C. Lien, A. M. Westermark, Z. Li, K. M. Sapp, M. Vander Heiden

This study shows caloric restriction inhibits tumor growth by reducing lipid availability and impairing stearoyl-CoA desaturase activity in cancer cells.

bioRxiv · Mar 9, 2020 · PreprintCancer Biology