Identification of epigenetic regulators of fibrotic transformation in cardiac fibroblasts through bulk and single-cell CRISPR screens
Laura Pilar Aguado‐Alvaro, Nerea Garitano, Wolfgang Esser‐Skala, Judith R. Sayers, Cynthia del Valle, Daniel Alameda, Julen Mendieta-Esteban, María Eréndira Calleja-Cervantes, Ainhoa Goñi‐Salaverri, Jon Zazpe, Anna Rosaria de Vito, Francesco P. Marchese, Diego Alignani, Juliana Cudini, Torsten Groß, , David Lara‐Astiaso
The paper identifies epigenetic regulators of fibrotic transformation in cardiac fibroblasts using bulk and single-cell CRISPR screens and shows KAT5 inhibition reduces fibrotic responses in human fibroblasts.
Nature Communications · Nov 26, 2025Peer-reviewedCell Biology