Author

A. E. Firth

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 2 Organism:human· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

K. Brown· 4 shared G. M. Cook· 2 shared I. Brierley· 2 shared V. Lulla· 2 shared A. D. Davidson· 1 shared A. M. Dinan· 1 shared A. P. A. Mockett· 1 shared A. Valpadashi· 1 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersMicrobiology

K. Brown

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

The SARS-CoV-2 protein ORF3c is a mitochondrial modulator of innate immunity

H. Stewart, Y. Lu, S. O'Keefe, A. Valpadashi, L. D. Cruz-Zaragoza, H. A. Michel, S. K. Nguyen, G. W. Carnell, N. Lukhovitskaya, R. Milligan, I. Jungreis, V. Lulla, A. D. Davidson, D. A. Matthews, S. High, , A. E. Firth

This study identifies ORF3c as a SARS-CoV-2 protein that localizes to mitochondria and inhibits IFN-β production without affecting NF-κB or JAK-STAT signaling.

bioRxiv · Nov 15, 2022Microbiology

Identification of RNA virus-derived RdRp sequences in publicly available transcriptomic datasets

I. Olendraite, K. Brown, A. E. Firth

The paper identifies RNA virus-derived RdRp sequences in transcriptomic datasets, expanding known viral diversity and providing curated HMM profiles for virus discovery.

bioRxiv · Oct 18, 2022 · PreprintMicrobiology

Ribosome profiling of porcine reproductive and respiratory syndrome virus reveals novel features of viral gene expression

G. M. Cook, K. Brown, P. Shang, Y. Li, L. Soday, A. M. Dinan, C. Tumescheit, A. P. A. Mockett, Y. Fang, A. E. Firth, I. Brierley

This study uses ribosome profiling to analyze PRRSV gene expression and reveals temporally regulated frameshifting and novel transcripts.

bioRxiv · Nov 17, 2021Pathology

pUL21 is a viral phosphatase adaptor that promotes herpes simplex virus replication and spread

T. H. Benedyk, J. Muenzner, V. Connor, Y. Han, K. Brown, K. J. Wijesinghe, Y. Zhuang, S. Colaco, G. A. Stoll, O. S. Tutt, S. Svobodova, D. I. Svergun, N. A. Bryant, J. E. Deane, A. E. Firth, , S. C. Graham

This study identifies pUL21 as a viral phosphatase adaptor that promotes HSV-1 replication and spread by directing dephosphorylation and antagonizing pUS3 kinase activity.

bioRxiv · Apr 13, 2021Microbiology

Manipulation of the unfolded protein response: a pharmacological strategy against coronavirus infection

L. Echavarria-Consuegra, G. M. Cook, I. Busnadiego, C. Lefevre, S. Keep, K. Brown, N. Doyle, G. Dowgier, K. Franaszek, N. A. Moore, S. G. Siddell, E. Bickerton, B. G. Hale, A. E. Firth, I. Brierley, N. Irigoyen

This paper investigates the unfolded protein response (UPR) in coronavirus infection and shows that pharmacological inhibition of the UPR significantly reduces viral replication.

bioRxiv · Mar 19, 2021Microbiology

A hidden gene in astroviruses encodes a cell-permeabilizing protein involved in virus release

V. Lulla, A. E. Firth

The paper identifies a conserved ORFX gene in astroviruses that encodes a cell-permeabilizing protein, XP, which facilitates virus release and contributes to viral replication and pathogenesis.

bioRxiv · Jun 6, 2019Microbiology